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Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History

Authors :
Veronica Santilli
Emma Concetta Manno
Carmela Giancotta
Chiara Rossetti
Nicola Cotugno
Donato Amodio
Gioacchino Andrea Rotulo
Annalisa Deodati
Roberto Bianchi
Giulia Lucignani
Daniela Longo
Massimiliano Valeriani
Paolo Palma
Source :
Vaccines. 10:1136
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination.

Details

ISSN :
2076393X
Volume :
10
Database :
OpenAIRE
Journal :
Vaccines
Accession number :
edsair.doi.dedup.....f3373c7827ebd49a4734bfd0632122af
Full Text :
https://doi.org/10.3390/vaccines10071136