Reader response:SYNGAP1 encephalopathy: A distinctive generalized developmental and epileptic encephalopathy

To move a condition from its genetic definition to a comprehensive syndrome description is an important step forward, and Vlaskamp et al.1 can be thanked for having done this for SYNGAP1 . The inclusion of 57 patients in a multicenter study provided an excellent, detailed delineation of the seizure syndrome. Attention is drawn to some reflex epileptic traits, including seizures precipitated by eating. In a recent study,2 we have particularly addressed this feature and noted that, whereas eating-induced seizures commonly are related to various phases of food intake, the trigger in our cases seemed, more narrowly, to be biting and chewing. They seem, thus, to represent a pathomechanism different from other eating-induced seizures. In addition, we saw that these patients were also commonly eye-closure sensitive.