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The evaluation of pretreatment neutrophil-lymphocyte ratio and derived neutrophil-lymphocyte ratio in patients with laryngeal neoplasms
- Source :
- Brazilian Journal of Otorhinolaryngology, Vol 85, Iss 5, Pp 578-587 (2019)
- Publication Year :
- 2018
-
Abstract
- Introduction: Systemic inflammatory biomarkers are promising predictive and prognostic factors for solid cancers. The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio are used to predict inflammation and used as biomarker in several malignancies. Objective: The purpose of this study was to demonstrate the diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio in patients with laryngeal neoplasms. Methods: A retrospective study was conducted on medical records involving 229 patients with benign, premalignant and malignant laryngeal neoplasms between 2002 and 2015. The diagnostic, predictive and prognostic role of neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were evaluated using uni– and multivariate analysis. Results: The neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were not statistically different between patients with benign, premalignant and malignant laryngeal neoplasms. Both neutrophil–lymphocyte ratio and derived neutrophil–lymphocyte ratio were predictive factors for stage, lymph node metastasis, and distant metastasis. Patients with high neutrophil–lymphocyte ratio value (≥4) had a poor prognosis when compared with patients with low neutrophil–lymphocyte ratio value (5 year, Overall Survival: 69.0% vs. 31.1%, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
Neutrophils
Lymphocyte
Gastroenterology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Preoperative Care
Carcinoma
Biomarkers, Tumor
Medicine
Humans
In patient
Lymphocyte Count
Stage (cooking)
030223 otorhinolaryngology
Laryngeal Neoplasms
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
business.industry
Retrospective cohort study
Laryngeal Neoplasm
Middle Aged
medicine.disease
lcsh:Otorhinolaryngology
Prognosis
lcsh:RF1-547
medicine.anatomical_structure
Otorhinolaryngology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Disease Progression
Biomarker (medicine)
Female
Neoplasm Recurrence, Local
business
Subjects
Details
- ISSN :
- 18088686
- Volume :
- 85
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Brazilian journal of otorhinolaryngology
- Accession number :
- edsair.doi.dedup.....f36116f4263d6270df1fee15919980dd