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Significant inverse association of equol-producer status with coronary artery calcification but not dietary isoflavones in healthy Japanese men
- Source :
- Br J Nutr
- Publication Year :
- 2017
- Publisher :
- Cambridge University Press (CUP), 2017.
-
Abstract
- Equol, a metabolite of the dietary isoflavone daidzein, is produced by the action of gut bacteria in some individuals who are termed as equol-producers. It is proposed to have stronger atheroprotective properties than dietary isoflavones. We examined a cross-sectional association of dietary isoflavones and equol-producer status with coronary artery calcification (CAC), a biomarker of coronary atherosclerosis, among men in Japan. A population-based sample of 272 Japanese men aged 40–49 years recruited from 2004 to 2007 was examined for serum isoflavones, serum equol, CAC and other factors. Equol-producers were classified as individuals having a serum level of equol >83 nm. The presence of CAC was defined as a coronary Ca score ≥10 Agatston units. The associations of dietary isoflavones and equol-producers with CAC were analysed using multiple logistic regression. The median of dietary isoflavones, equol and CAC were 512·7 (interquartile range (IQR) 194·1, 1170·0), 9·1 (IQR 0·10, 33·1) and 0·0 (IQR 0·0, 1·0) nm, respectively. Prevalence of CAC and equol-producers was 9·6 and 16·0 %, respectively. Dietary isoflavones were not significantly associated with CAC. After multivariable adjustment, the OR for the presence of CAC in equol-producers compared with equol non-producers was 0·10 (95 % CI 0·01, 0·90, P
- Subjects :
- Adult
Male
0301 basic medicine
Population
Medicine (miscellaneous)
Physiology
030204 cardiovascular system & hematology
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Japan
Interquartile range
Odds Ratio
Humans
Medicine
cardiovascular diseases
education
Coronary atherosclerosis
education.field_of_study
030109 nutrition & dietetics
Nutrition and Dietetics
Bacteria
business.industry
Daidzein
Calcinosis
nutritional and metabolic diseases
food and beverages
Equol
Middle Aged
Isoflavones
Atherosclerosis
Coronary Vessels
Diet
Coronary Calcium Score
Cross-Sectional Studies
Logistic Models
Phenotype
chemistry
Biomarker (medicine)
business
Biomarkers
Subjects
Details
- ISSN :
- 14752662 and 00071145
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- British Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....f36f2c2a815d83b914ec4e370d6118ce
- Full Text :
- https://doi.org/10.1017/s000711451600458x