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Hispanic ethnicity as a moderator of the effects of aerobic and resistance exercise in survivors of breast cancer
- Source :
- Cancer. 125:910-920
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- BACKGROUND: Metabolic syndrome (MSY) is associated with an increased risk of cardiovascular disease, type 2 diabetes, and recurrence in breast cancer survivors (BCS). MSY is 1.5 times more common in Hispanic women compared with non-Hispanic women. Although exercise mitigates MSY in BCS, to the best of the authors’ knowledge, few studies to date have focused on minorities. This secondary analysis examined ethnicity as a moderator of the effects of a 16-week aerobic and resistance exercise intervention on MSY, sarcopenic obesity, and serum biomarkers in BCS. METHODS: A total of 100 eligible BCS were randomized to exercise (50 BCS) or usual care (50 BCS). The exercise intervention promoted moderate to vigorous aerobic and resistance exercise 3 times a week for 16 weeks. MSY z scores, sarcopenic obesity, and serum biomarkers were measured at baseline, after the intervention, and at the 28-week follow-up (exercise group only). Linear mixed models adjusted for baseline values of the outcome, age, disease stage, adjuvant treatment, and recent physical activity were used to evaluate effect modification by ethnicity. RESULTS: The study sample was 57% Hispanic BCS (HBCS) and 43% non-Hispanic BCS (NHBCS). HBCS were younger, of greater adiposity, and had been diagnosed with more advanced cancers compared with NHBCS (P
- Subjects :
- Adult
Sarcopenia
Cancer Research
medicine.medical_specialty
Breast Neoplasms
Disease
Type 2 diabetes
Standard score
Article
03 medical and health sciences
0302 clinical medicine
Breast cancer
Cancer Survivors
Internal medicine
medicine
Humans
Sarcopenic obesity
Obesity
030212 general & internal medicine
Exercise
Aged
business.industry
Resistance Training
Hispanic or Latino
Middle Aged
medicine.disease
Confidence interval
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Female
Metabolic syndrome
business
Biomarkers
Subjects
Details
- ISSN :
- 10970142 and 0008543X
- Volume :
- 125
- Database :
- OpenAIRE
- Journal :
- Cancer
- Accession number :
- edsair.doi.dedup.....f37162341ca8800fc06f46b4f61e375e
- Full Text :
- https://doi.org/10.1002/cncr.31879