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Sister chromatid exchange frequencies in lymphocytes of oral cancer patients seem to be influenced by drinking habits
- Source :
- Carcinogenesis. 15:1603-1607
- Publication Year :
- 1994
- Publisher :
- Oxford University Press (OUP), 1994.
-
Abstract
- Sister chromatid exchange (SCE) values were determined in the lymphocytes of 24 oral cancer patients before therapy and in the lymphocytes of 24 control persons standardized with respect to sex, age and smoking habits. Oral cancer patients showed significantly elevated SCE values (mean 7.82 versus 6.42). In both groups the highest SCE values were found in the subgroups with the highest alcohol consumption. A significant correlation between SCE and gamma-glutamyltranspeptidase (GGT) values by Spearman correlation analysis was detected in the combined group (cancer patients and control persons) (n = 32, r = 0.40, P = 0.023). The SCE values in the oral cancer patients were weakly correlated (Pearson) to DNA adduct levels (n = 22, r = 0.39, P = 0.068) and DNA single-strand breakage frequencies (n = 12, r = 0.56, P = 0.054) in lymphocytes. The correlation (Pearson) between SCE values and DNA strand breakage values in lymphocytes was significant (n = 10, r = 0.67, P = 0.036) in smoking cancer patients. The increase of SCE values with respect to alcohol drinking habits underlines epidemiologic findings that alcohol is an important co-carcinogen in many cancers, especially in oral cancers. Because of the influences on SCE and adduct levels in lymphocytes, alcohol drinking habits should be controlled as broadly as possible in biomarker studies.
- Subjects :
- Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
Alcohol Drinking
Lymphocyte
Physiology
Alcohol
Sister chromatid exchange
chemistry.chemical_compound
DNA adduct
Humans
Medicine
Lymphocytes
Carcinogen
Aged
Aged, 80 and over
business.industry
Smoking
Cancer
DNA
gamma-Glutamyltransferase
General Medicine
Middle Aged
medicine.disease
medicine.anatomical_structure
Drinking habits
chemistry
Biomarker (medicine)
Female
Mouth Neoplasms
business
Sister Chromatid Exchange
DNA Damage
Subjects
Details
- ISSN :
- 14602180 and 01433334
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Carcinogenesis
- Accession number :
- edsair.doi.dedup.....f382ce74dea81b521d3c4a7608ca36ae