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Lesions of intestinal epithelium by ingestion of bean lectins in rats
- Source :
- Journal of nutritional science and vitaminology. 35(4)
- Publication Year :
- 1989
-
Abstract
- Wistar rats were submitted to the action of active lectins from common dry beans (Phaseolus vulgaris) and from jack beans (Canavalia ensiformis, DC). Raw common bean was offered to the rats in an otherwise balanced diet to make 10% protein as the sole protein source. A single dose of 20 mg of jack bean lectin (concanavalin A) was given by gastric intubation. Half of the rats receiving raw bean died within 22 days of experiment. Histological findings showed ulceration and necrosis of the intestinal villi in the surviving rats. In some cases the lesions reached also the submucosa. Gastric intubation of concanavalin A caused intense scaling off in the apical portion of the villi.
- Subjects :
- Male
medicine.medical_specialty
Necrosis
Duodenum
Medicine (miscellaneous)
Intestinal mucosa
Internal medicine
Lectins
Weight Loss
medicine
Concanavalin A
Ingestion
Animals
Intestinal Mucosa
Phytohemagglutinins
Intubation, Gastrointestinal
Nutrition and Dietetics
Plants, Medicinal
biology
digestive, oral, and skin physiology
food and beverages
Lectin
Fabaceae
Rats, Inbred Strains
biology.organism_classification
Diet
Rats
Endocrinology
Canavalia ensiformis
Immunology
biology.protein
Phaseolus
medicine.symptom
Plant Lectins
Subjects
Details
- ISSN :
- 03014800
- Volume :
- 35
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of nutritional science and vitaminology
- Accession number :
- edsair.doi.dedup.....f388ca1d1512e6d50ee2e40f20241e75