Back to Search
Start Over
Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes
- Source :
- PLoS ONE, PLoS One, 8, PLoS ONE, Vol 8, Iss 2, p e56488 (2013), PLoS One, 8, 2
- Publication Year :
- 2012
-
Abstract
- Contains fulltext : 125353.pdf (Publisher’s version ) (Open Access) BACKGROUND: Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of beta-cell function and metabolic control was examined. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve beta-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 microg calcitriol per day or placebo (1:1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (P
- Subjects :
- Male
medicine.medical_treatment
Bone remodeling
Endocrinology
Osteogenesis
Insulin-Secreting Cells
Insulin
Age of Onset
Vitamin D
Child
Multidisciplinary
biology
C-Peptide
Mitochondrial medicine Energy and redox metabolism [IGMD 8]
Vitamins
Osteocalcin
Medicine
Female
Collagen
medicine.drug
Research Article
Peak bone mass
Adult
medicine.medical_specialty
Calcitriol
Adolescent
Clinical Research Design
Science
Bone and Mineral Metabolism
Bone resorption
Autoimmune Diseases
Rheumatology
Internal medicine
medicine
Humans
Bone Resorption
Retrospective Studies
Nutrition
Glycated Hemoglobin
Diabetic Endocrinology
Type 1 diabetes
Endocrine Physiology
business.industry
Diabetes Mellitus Type 1
medicine.disease
Peptide Fragments
Diabetes Mellitus, Type 1
Metabolic control analysis
biology.protein
Clinical Immunology
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....f38d98fc5d85efb627193304cbfd0243