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Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer

Authors :
R. Jeroen A. van Moorselaar
Yves J. L. Bodar
Dennie Meijer
Henk B. Luiting
André N. Vis
Jakko A. Nieuwenhuijzen
Thelma Witteveen
B.H.E. Jansen
Monique J. Roobol
Henk G. van der Poel
Daniela E. Oprea-Lager
Sebastiaan Remmers
Eva E. Schaake
P. Meijnen
Pim J. van Leeuwen
N. Harry Hendrikse
Tessa Brabander
Martijn B. Busstra
Maurits Wondergem
Urology
Radiology and nuclear medicine
CCA - Imaging and biomarkers
Radiation Oncology
Radiology & Nuclear Medicine
Source :
Meijer, D, Luiting, H B, van Leeuwen, P J, Remmers, S, Jansen, B H E, Bodar, Y J L, Witteveen, T, Schaake, E E, van der Poel, H G, Wondergem, M, Busstra, M B, Nieuwenhuijzen, J A, Meijnen, P, Brabander, T, van Moorselaar, R J A, Hendrikse, N H, Oprea-Lager, D E, Roobol, M J & Vis, A N 2021, ' Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer ', The Journal of Urology, vol. 205, no. 4, pp. 1100-1109 . https://doi.org/10.1097/JU.0000000000001437, The Journal of Urology, 205(4), 1100-1109. Elsevier Inc., The Journal of urology, 205(4), 1100-1109. Elsevier Inc.
Publication Year :
2021

Abstract

PURPOSE: We assessed predictors of short-term oncologic outcomes of patients who underwent salvage radiation therapy for biochemical recurrence after robot-assisted laparoscopic radical prostatectomy without evidence of metastases on prostate specific membrane antigen positron emission tomography/computerized tomography. MATERIALS AND METHODS: We retrospectively analyzed 194 patients with biochemical recurrence after robot-assisted laparoscopic radical prostatectomy who underwent prostate specific membrane antigen positron emission tomography/computerized tomography prior to salvage radiation therapy. Patients with lymph node or distant metastases on restaging imaging or at the time of extended pelvic lymph node dissection during robot-assisted laparoscopic radical prostatectomy were excluded, as were patients who received androgen deprivation therapy during or prior to salvage radiation therapy. A multivariable logistic regression analysis was performed to assess predictors of treatment response, defined as prostate specific antigen value ≤0.1 ng/ml after salvage radiation therapy. RESULTS: Overall treatment response after salvage radiation therapy was 75% (146/194 patients). On multivariable analysis, prostate specific antigen value at initiation of salvage radiation therapy (OR 0.42, 95% CI 0.27-0.62, p

Details

Language :
English
ISSN :
00225347
Database :
OpenAIRE
Journal :
Meijer, D, Luiting, H B, van Leeuwen, P J, Remmers, S, Jansen, B H E, Bodar, Y J L, Witteveen, T, Schaake, E E, van der Poel, H G, Wondergem, M, Busstra, M B, Nieuwenhuijzen, J A, Meijnen, P, Brabander, T, van Moorselaar, R J A, Hendrikse, N H, Oprea-Lager, D E, Roobol, M J & Vis, A N 2021, ' Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer ', The Journal of Urology, vol. 205, no. 4, pp. 1100-1109 . https://doi.org/10.1097/JU.0000000000001437, The Journal of Urology, 205(4), 1100-1109. Elsevier Inc., The Journal of urology, 205(4), 1100-1109. Elsevier Inc.
Accession number :
edsair.doi.dedup.....f391c18d009c8c906662d8500d803051
Full Text :
https://doi.org/10.1097/JU.0000000000001437