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Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer
- Source :
- Meijer, D, Luiting, H B, van Leeuwen, P J, Remmers, S, Jansen, B H E, Bodar, Y J L, Witteveen, T, Schaake, E E, van der Poel, H G, Wondergem, M, Busstra, M B, Nieuwenhuijzen, J A, Meijnen, P, Brabander, T, van Moorselaar, R J A, Hendrikse, N H, Oprea-Lager, D E, Roobol, M J & Vis, A N 2021, ' Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer ', The Journal of Urology, vol. 205, no. 4, pp. 1100-1109 . https://doi.org/10.1097/JU.0000000000001437, The Journal of Urology, 205(4), 1100-1109. Elsevier Inc., The Journal of urology, 205(4), 1100-1109. Elsevier Inc.
- Publication Year :
- 2021
-
Abstract
- PURPOSE: We assessed predictors of short-term oncologic outcomes of patients who underwent salvage radiation therapy for biochemical recurrence after robot-assisted laparoscopic radical prostatectomy without evidence of metastases on prostate specific membrane antigen positron emission tomography/computerized tomography. MATERIALS AND METHODS: We retrospectively analyzed 194 patients with biochemical recurrence after robot-assisted laparoscopic radical prostatectomy who underwent prostate specific membrane antigen positron emission tomography/computerized tomography prior to salvage radiation therapy. Patients with lymph node or distant metastases on restaging imaging or at the time of extended pelvic lymph node dissection during robot-assisted laparoscopic radical prostatectomy were excluded, as were patients who received androgen deprivation therapy during or prior to salvage radiation therapy. A multivariable logistic regression analysis was performed to assess predictors of treatment response, defined as prostate specific antigen value ≤0.1 ng/ml after salvage radiation therapy. RESULTS: Overall treatment response after salvage radiation therapy was 75% (146/194 patients). On multivariable analysis, prostate specific antigen value at initiation of salvage radiation therapy (OR 0.42, 95% CI 0.27-0.62, p
- Subjects :
- Male
Biochemical recurrence
medicine.medical_specialty
Urology
medicine.medical_treatment
Prostate cancer
Robotic Surgical Procedures
SDG 3 - Good Health and Well-being
Salvage radiation
Positron Emission Tomography Computed Tomography
Biomarkers, Tumor
medicine
Glutamate carboxypeptidase II
Humans
Aged
Neoplasm Staging
Retrospective Studies
Prostatectomy
Salvage Therapy
medicine.diagnostic_test
business.industry
Prostatic Neoplasms
Middle Aged
Prostate-Specific Antigen
medicine.disease
Radiation therapy
Positron emission tomography
Radiology
Tomography
business
Subjects
Details
- Language :
- English
- ISSN :
- 00225347
- Database :
- OpenAIRE
- Journal :
- Meijer, D, Luiting, H B, van Leeuwen, P J, Remmers, S, Jansen, B H E, Bodar, Y J L, Witteveen, T, Schaake, E E, van der Poel, H G, Wondergem, M, Busstra, M B, Nieuwenhuijzen, J A, Meijnen, P, Brabander, T, van Moorselaar, R J A, Hendrikse, N H, Oprea-Lager, D E, Roobol, M J & Vis, A N 2021, ' Prostate Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography in the Evaluation of Initial Response in Candidates Who Underwent Salvage Radiation Therapy after Radical Prostatectomy for Prostate Cancer ', The Journal of Urology, vol. 205, no. 4, pp. 1100-1109 . https://doi.org/10.1097/JU.0000000000001437, The Journal of Urology, 205(4), 1100-1109. Elsevier Inc., The Journal of urology, 205(4), 1100-1109. Elsevier Inc.
- Accession number :
- edsair.doi.dedup.....f391c18d009c8c906662d8500d803051
- Full Text :
- https://doi.org/10.1097/JU.0000000000001437