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Radioprotective effect and other biological benefits associated with flavonoids
- Source :
- Tropical Journal of Pharmaceutical Research; Vol 15, No 5 (2016); 1099-1108
- Publication Year :
- 2016
- Publisher :
- Tropical Journal of Pharmaceutical Research, 2016.
-
Abstract
- Ionizing radiation has the potential to cause extensive damage to living organisms. It can directly act on DNA, proteins and lipids, resulting in ionizing excitation and chemical bond cleavage, which can lead to molecular and cellular damage. Ionizing radiation can hydrolyze water molecules in the body, resulting in increased numbers of free radicals with strong oxidation ability. This process indirectly leads to tissue degeneration and necrosis, which can possibly result in cancer. In this paper, the intervention mechanism of flavonoids on ionizing radiation was analyzed. It has been revealed that the intervention mechanism associated with flavonoids may offer protective properties for DNA, prevent scavenging free radicals, and protect against auto-immune damage. In addition, this invention mechanism can protect the hematopoietic system and reduce inflammation Keywords: Ionizing radiation, Flavonoids, Radioprotective mechanisms, Molecular and cellular damage, DNA, Hematopoietic system, Inflammation
- Subjects :
- 0301 basic medicine
Necrosis
Chemistry
Mechanism (biology)
Radical
fungi
food and beverages
Pharmaceutical Science
Cancer
Inflammation
medicine.disease
Ionizing radiation
Tissue Degeneration
03 medical and health sciences
chemistry.chemical_compound
030104 developmental biology
0302 clinical medicine
Biochemistry
030220 oncology & carcinogenesis
medicine
Biophysics
Pharmacology (medical)
medicine.symptom
Ionizing radiation, Flavonoids, Radioprotective mechanisms, Molecular and cellular damage, DNA, Hematopoietic system, Inflammation
DNA
Subjects
Details
- Language :
- English
- ISSN :
- 15965996 and 15969827
- Database :
- OpenAIRE
- Journal :
- Tropical Journal of Pharmaceutical Research
- Accession number :
- edsair.doi.dedup.....f3a04dc229d7585a4e46a52d811869f8