Inhibition of rat brain cytochrome oxidase activity by pyrolysed products of methyl isocyanate

Authors :: D.P. Chattopadhyay
B.K. Bhattacharya
R.C. Malhotra
Source :: Toxicology Letters. 37:131-134
Publication Year :: 1987
Publisher :: Elsevier BV, 1987.
Abstract: The effects were studied of methyl isocyanate (MIC) and its thermally degraded products (dMIC) on rat brain cytochrome oxidase activity. Pure MIC did not inhibit brain cytochrome oxidase activity. A significant inhibition of brain cytochrome oxidase activity by dMIC was observed both in vivo and in vitro. The presence of cyanide in pyrolysed products of MIC has also been confirmed by chemical methods.

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