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Self-Actuated, Thermo-Responsive Hydrogel Valves for Lab on a Chip
- Source :
- Biomedical Microdevices. 7:313-322
- Publication Year :
- 2005
- Publisher :
- Springer Science and Business Media LLC, 2005.
-
Abstract
- An easy to fabricate, thermally-actuated, self-regulated hydrogel valve for flow control in pneumatically driven, microfluidic systems is described. This microvalve takes advantage of the properties of the hydrogel, poly(N-isopropylacrylamide), as well as the aqueous fluid itself to realize flow control. The valve was designed for use in a diagnostic system fabricated with polycarbonate and aimed at the detection of pathogens in oral fluids at the location of the sample collection. The paper describes the construction and characterization of the hydrogel valves and their application for flow control, sample and reagent metering, sample distribution into multiple analysis paths, and the sealing of a polymerase chain reaction (PCR) reactor to suppress bubble formation. The hydrogel-based flow control is electronically addressable, does not require any moving parts, introduces minimal dead volume, is leakage and contaminant free, and is biocompatible.
- Subjects :
- Materials science
Microfluidics
Acrylic Resins
Biomedical Engineering
Biocompatible Materials
Nanotechnology
Polymerase Chain Reaction
law.invention
law
Materials Testing
Computer Simulation
Metering mode
Molecular Biology
Leakage (electronics)
Temperature
technology, industry, and agriculture
Hydrogels
Equipment Design
Microfluidic Analytical Techniques
Lab-on-a-chip
Equipment Failure Analysis
Flow control (fluid)
Models, Chemical
Reagent
Flow Injection Analysis
Computer-Aided Design
Sample collection
Liquid bubble
Subjects
Details
- ISSN :
- 15728781 and 13872176
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Biomedical Microdevices
- Accession number :
- edsair.doi.dedup.....f3a93dab88a5eff8bb8f7b766475c63e