Back to Search
Start Over
C-reactive protein is a significant predictor of improved survival in patients with advanced non-small cell lung cancer
- Source :
- Medicine
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer Health, 2019.
-
Abstract
- This study tries to evaluate the associations between circulating C-reactive protein (CRP) and the overall survival of patients with non-small cell lung cancer (NSCLC). One hundred ninety-two patients with advanced NSCLC who treated with chemotherapy were enrolled in this study. The cut-off value of CRP concentration was 5.0 mg/L. The patients were divided into low, intermediate and high 3 groups respectively according to the baseline level of CRP before the treatment. Kaplan–Meier analysis and Cox proportional-hazard models were used to evaluate the relationship between the CRP and overall survival time of patients. After adjusting for age, gender, smoking history, pathologic type, CRP was a significant independent impact which predicts the survival prognosis of patients with NSCLC. For all patients, the hazard ratio with high CRP levels for NSCLC-specific survival was 1.83 [95%confidenceinterval (CI) = 0.96, 3.48] compared with low CRP levels. The level of CRP was significantly correlated with survival time (hazard ratio = 1.77; 95% CI = 0.73, 4.26) for the patient with first-line chemotherapy. Patients with high level of circulating CRP also responded poorly to chemotherapy. A high level of circulating CRP was associated with a poor response and worse survival in patients with NSCLC.
- Subjects :
- Male
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
Observational Study
Gastroenterology
C-reactive protein
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Carcinoma, Non-Small-Cell Lung
medicine
Carcinoma
Humans
030212 general & internal medicine
Lung cancer
Survival rate
non-small cell lung cancer
Neoplasm Staging
Retrospective Studies
Chemotherapy
biology
business.industry
Hazard ratio
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Prognosis
Survival Rate
030220 oncology & carcinogenesis
Predictive value of tests
biology.protein
Female
business
Research Article
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 98
- Issue :
- 26
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....f3c39da4a6a957b05ad516394a098778