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Functional regulatory roles of microRNAs in atherosclerosis
- Source :
- Clinica Chimica Acta. 460:164-171
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- MicroRNAs are a group of endogenously small non-coding RNA molecules that downregulate gene expression at the post-transcriptional level through binding to the 3'UTR of target mRNAs. Recent findings have revealed a key role for microRNAs in the pathophysiological processes of atherosclerosis. As a complex disease, atherosclerosis is influenced by a combination of multiple genes and environmental factors. Both of them play a role in atherogenesis by affecting different types of cells (such as endothelial cell, vascular smooth muscle cell and monocyte/macrophage) function. MicroRNAs control the senescence and dysfunction of endothelial cells, proliferation and migration of vascular smooth muscle cells, and macrophage-driven cytokine production and polarization. By these effects, microRNAs can influence the processes of atherosclerosis and may represent new molecular targets for therapy.
- Subjects :
- 0301 basic medicine
Vascular smooth muscle
medicine.medical_treatment
Clinical Biochemistry
Cell
Inflammation
Biology
Biochemistry
Muscle, Smooth, Vascular
03 medical and health sciences
Gene expression
microRNA
medicine
Humans
Macrophage
Molecular Targeted Therapy
Macrophages
Biochemistry (medical)
Endothelial Cells
General Medicine
Atherosclerosis
Cell biology
Endothelial stem cell
MicroRNAs
030104 developmental biology
Cytokine
medicine.anatomical_structure
medicine.symptom
Subjects
Details
- ISSN :
- 00098981
- Volume :
- 460
- Database :
- OpenAIRE
- Journal :
- Clinica Chimica Acta
- Accession number :
- edsair.doi.dedup.....f3fba8b1968b68f152333299192ca61b