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Neuronal antibody detection and improved lung cancer prediction in Lambert-Eaton myasthenic syndrome
- Source :
- Journal of neuroimmunology. 340
- Publication Year :
- 2019
-
Abstract
- Since approximately 50% of patients with Lambert-Eaton myasthenic syndrome (LEMS) subsequently develop small-cell lung cancer (SCLC), it is important to be able to predict cancer occurrence in these patients at neurological presentation. We aimed to determine whether circulating biomarkers were effective and objective predictors of cancer development in LEMS. We found that the presence of either SOX2, N-type voltage gated calcium channel or GABAb antibodies at LEMS diagnosis was highly sensitive (84%) and specific (87%) for the detection of SCLC. Screening for SOX2 and neuronal antibodies is a useful adjunct to clinical predictive scoring tools in predicting SCLC in LEMS.
- Subjects :
- 0301 basic medicine
Oncology
Adult
Male
medicine.medical_specialty
Lung Neoplasms
Immunology
Autoantigens
03 medical and health sciences
0302 clinical medicine
SOX2
Internal medicine
medicine
Biomarkers, Tumor
Immunology and Allergy
Humans
Lung cancer
Aged
Autoantibodies
Aged, 80 and over
Neurons
biology
Neuronal Antibody
business.industry
Cancer
Middle Aged
medicine.disease
Small Cell Lung Carcinoma
respiratory tract diseases
Circulating biomarkers
Lambert-Eaton Myasthenic Syndrome
030104 developmental biology
Neurology
biology.protein
Female
Neurology (clinical)
Cancer development
Antibody
business
Lambert-Eaton myasthenic syndrome
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 18728421
- Volume :
- 340
- Database :
- OpenAIRE
- Journal :
- Journal of neuroimmunology
- Accession number :
- edsair.doi.dedup.....f403567b71788ca58759b22c4cd25872