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The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care:a randomised clinical controlled trial
- Source :
- Kassavou, A, Mirzaei, V, Shpendi, S, Brimicombe, J, Chauhan, J, Bhattacharya, D, Naughton, F, Hardeman, W, Eborall, H, Van Emmenis, M, De Simoni, A, Takhar, A, Gupta, P, Patel, P, Mascolo, C, Prevost, A T, Morris, S, Griffin, S, McManus, R, Mant, J & Sutton, S 2021, ' The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care : a randomised clinical controlled trial ', Scientific Reports, vol. 11, no. 8897 . https://doi.org/10.1038/s41598-021-88170-2, Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Publication Year :
- 2021
-
Abstract
- The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and 7.9% attrition rate. Patients were randomly allocated to two groups: the intervention group (n = 61) received the PAM intervention as an adjunct to usual care; the control group (n = 40) received usual care only. At 3 months, biochemically validated medication adherence was improved by 20% (95% CI 3–36%) in the intervention than control, and systolic blood pressure was reduced by 9.16 mmHg (95% CI 5.69–12.64) in intervention than control. Improvements in medication adherence and reductions in blood pressure suggested potential intervention effectiveness. For a subsample of patients, improvements in medication adherence and reductions in full lipid profile (cholesterol 1.39 mmol/mol 95% CI 0.64–1.40) and in glycated haemoglobin (3.08 mmol/mol, 95% CI 0.42–5.73) favoured the intervention. A larger trial will obtain rigorous evidence about the potential clinical effectiveness and cost-effectiveness of the intervention.Trial registration Trial date of first registration 28/01/2019. ISRCTN74504989. https://doi.org/10.1186/ISRCTN74504989.
- Subjects :
- Male
medicine.medical_specialty
692/700
Treatment adherence
Science
692/308
Cardiology
Medication adherence
692/1537
Primary care
030204 cardiovascular system & hematology
ISRCTN74504989
Article
law.invention
Medication Adherence
03 medical and health sciences
0302 clinical medicine
Medical research
Randomized controlled trial
law
Intervention (counseling)
Internal medicine
medicine
Psychology
Humans
030212 general & internal medicine
Aged
Glycated Hemoglobin
Multidisciplinary
medicine.diagnostic_test
Primary Health Care
business.industry
Health care
Middle Aged
692/4019
United Kingdom
Blood pressure
Usual care
Hypertension
Medicine
Female
631/477
business
Lipid profile
Health occupations
ISRCTN
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Kassavou, A, Mirzaei, V, Shpendi, S, Brimicombe, J, Chauhan, J, Bhattacharya, D, Naughton, F, Hardeman, W, Eborall, H, Van Emmenis, M, De Simoni, A, Takhar, A, Gupta, P, Patel, P, Mascolo, C, Prevost, A T, Morris, S, Griffin, S, McManus, R, Mant, J & Sutton, S 2021, ' The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care : a randomised clinical controlled trial ', Scientific Reports, vol. 11, no. 8897 . https://doi.org/10.1038/s41598-021-88170-2, Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021), Scientific Reports
- Accession number :
- edsair.doi.dedup.....f40477bb61db6880e352e4ac148246d1