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Local Gene Transfer of phVEGF-2 Plasmid by Gene-Eluting Stents
- Source :
- Circulation. 110:36-45
- Publication Year :
- 2004
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2004.
-
Abstract
- Background— Drug-eluting stents represent a useful strategy for the prevention of restenosis using various antiproliferative drugs. These strategies share the liability of impairing endothelial recovery, thereby altering the natural biology of the vessel wall and increasing the associated risk of stent thrombosis. Accordingly, we tested the hypothesis that local delivery via gene-eluting stent of naked plasmid DNA encoding for human vascular endothelial growth factor (VEGF)-2 could achieve similar reductions in neointima formation while accelerating, rather than inhibiting, reendothelialization. Methods and Results— phVEGF 2-plasmid (100 or 200 μg per stent)–coated BiodivYsio phosphorylcholine polymer stents versus uncoated stents were deployed in a randomized, blinded fashion in iliac arteries of 40 normocholesterolemic and 16 hypercholesterolemic rabbits. Reendothelialization was nearly complete in the VEGF stent group after 10 days and was significantly greater than in control stents (98.7±1% versus 79.0±6%, P 2 , P P Conclusions— Acceleration of reendothelialization via VEGF-2 gene–eluting stents provides an alternative treatment strategy for the prevention of restenosis. VEGF-2 gene–eluting stents may be considered as a stand-alone or combination therapy.
- Subjects :
- Male
Neointima
medicine.medical_specialty
Endothelium
Genetic enhancement
medicine.medical_treatment
Urology
Gene Expression
Arterial Occlusive Diseases
Nitric Oxide
chemistry.chemical_compound
Plasmid
Restenosis
Physiology (medical)
Animals
Medicine
Ultrasonography
Vascular Endothelial Growth Factors
Phosphorylcholine
business.industry
Stem Cells
Gene Transfer Techniques
Stent
Genetic Therapy
medicine.disease
Combined Modality Therapy
Surgery
Vascular endothelial growth factor
medicine.anatomical_structure
chemistry
Stents
Endothelium, Vascular
Rabbits
Cardiology and Cardiovascular Medicine
business
Plasmids
Subjects
Details
- ISSN :
- 15244539 and 00097322
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- Circulation
- Accession number :
- edsair.doi.dedup.....f405233b8b15fe77f7774cf7c149dd7b