The effect of dimethylsulfoxide on the lipid composition of inducible and non inducible Friend leukemia cells

Changes in phospholipids and in fatty acid composition were observed when Friend leukemia cells (FLC), but not the resistant one (RFLC) were exposed to DMSO. As a result of these changes, the molar ratio of phosphatidyl choline (PC) to phosphatidyl ethanolamine (PE) and the relative amount of arachidonic acid (20:4) isolated from total lipids, PC and PE increased in differentiated cells. We therefore conclude that erythroid differentiation induced by DMSO is related to changes in the lipid components of FLC membranes.