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The Use of Chromosomal Microarray Analysis in Prenatal Diagnosis
- Source :
- Obstetrics and gynecology clinics of North America. 45(1)
- Publication Year :
- 2018
-
Abstract
- Chromosomal microarray analysis (CMA) identifies microdeletions and duplications undetected on karyotype analysis. Copy number variants (CNVs) occur in 1% to 1.7% of all pregnancies, with clinical implications. All women undergoing invasive testing for routine indications should be offered microarray. Clinically significant CNVs are seen in approximately 6% of pregnancies with ultrasound anomalies, making CMAs the current standard of cytogenomic analysis. Clinicians should be familiar with different technologies and laboratory reporting practices. Pretest counseling is imperative and, when CMA results are abnormal, posttest counseling should be in-depth and conducted by a genetic counselor or clinical geneticist.
- Subjects :
- 0301 basic medicine
Microarray
Genetic counseling
Prenatal diagnosis
Chromosome Disorders
030105 genetics & heredity
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Pregnancy
Prenatal Diagnosis
Medicine
Humans
Copy-number variation
Genetic Testing
Chromosome Aberrations
030219 obstetrics & reproductive medicine
Microarray analysis techniques
business.industry
Obstetrics and Gynecology
Karyotype
Geneticist
Microarray Analysis
humanities
Laboratory reporting
Female
business
Subjects
Details
- ISSN :
- 15580474
- Volume :
- 45
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Obstetrics and gynecology clinics of North America
- Accession number :
- edsair.doi.dedup.....f415cf90cfe80d4551a3c12217b0468e