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Plasma cytokine changes in relation to exercise intensity and muscle damage
- Source :
- European journal of applied physiology. 95(5-6)
- Publication Year :
- 2005
-
Abstract
- The purpose of this study was to compare the effects of exercise intensity and exercise-induced muscle damage on changes in anti-inflammatory cytokines and other inflammatory mediators. Nine well-trained male runners completed three different exercise trials on separate occasions: ( 1) level treadmill running at 60% VO2max (moderate-intensity trial) for 60 min; (2) level treadmill running at 85% VO2max (high-intensity trial) for 60 min; (3) downhill treadmill running ( - 10% gradient) at 60% VO2 max (downhill running trial) for 45 min. Blood was sampled before, immediately after and 1 h after exercise. Plasma was analyzed for interleukin-1 receptor antagonist (IL-1ra), IL-4, IL-5, IL-10, IL-12p40, IL-13, monocyte chemotactic protein-1 (MCP-1), prostaglandin E-2, leukotriene B-4 and heat shock protein 70 (HSP70). The plasma concentrations of IL-1ra, IL-12p40, MCP-1 and HSP70 increased significantly (P< 0.05) after all three trials. Plasma prostaglandin E-2 concentration increased significantly after the downhill running and high-intensity trials, while plasma IL-10 concentration increased significantly only after the high-intensity trial. IL-4 and leukotriene B4 did not increase significantly after exercise. Plasma IL-1ra and IL-10 concentrations were significantly higher ( P< 0.05) after the high-intensity trial than after both the moderate-intensity and downhill running trials. Therefore, following exercise up to 1 h duration, exercise intensity appears to have a greater effect on anti-inflammatory cytokine production than exercise-induced muscle damage.
- Subjects :
- Adult
Male
medicine.medical_specialty
Physiology
Leukotriene B4
Receptor expression
Sialoglycoproteins
Prostaglandin
Physical exercise
Dinoprostone
chemistry.chemical_compound
Endurance training
Physiology (medical)
Internal medicine
medicine
Humans
Orthopedics and Sports Medicine
HSP70 Heat-Shock Proteins
Exercise physiology
Muscle, Skeletal
Exercise
Chemokine CCL2
business.industry
Interleukin-12 Subunit p40
Interleukins
Public Health, Environmental and Occupational Health
VO2 max
General Medicine
Interleukin-12
Interleukin-10
Interleukin 1 Receptor Antagonist Protein
Endocrinology
chemistry
Exercise intensity
Cytokines
business
Subjects
Details
- ISSN :
- 14396319
- Volume :
- 95
- Issue :
- 5-6
- Database :
- OpenAIRE
- Journal :
- European journal of applied physiology
- Accession number :
- edsair.doi.dedup.....f444e7541be906303bc179ec1ef2f01c