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Treatment of spasticity with botulinum toxin: A double-blind study
- Source :
- Annals of Neurology. 28:512-515
- Publication Year :
- 1990
- Publisher :
- Wiley, 1990.
-
Abstract
- We studied the effect of botulinum-A toxin on spasticity of the leg adductors in 9 patients who were either chair-bound or bed-bound with chronic stable multiple sclerosis. We injected botulinum toxin (400 mouse units) or placebo into the adductor muscles in a randomized, crossover, double-blind design. Two physicians, who were unaware of the treatment order, used an objective rating scale and independently assessed the patients; interobserver correlation was excellent (r = 0.93-0.81). We found that botulinum toxin produced a significant reduction in spasticity (p = 0.009) and a significant improvement in the ease of nursing care (p = 0.009). There were no adverse effects during this short-term trial. This is the first demonstration of the beneficial effect of botulinum toxin on focal spastic muscle contractions.
- Subjects :
- Adult
Male
medicine.medical_specialty
Botulinum Toxins
Multiple Sclerosis
Pilot Projects
Placebo
medicine.disease_cause
Severity of Illness Index
law.invention
Random Allocation
Nursing care
Double-Blind Method
Randomized controlled trial
law
Spastic
medicine
Humans
Spasticity
Adverse effect
Aged
business.industry
Hygiene
Middle Aged
Botulinum toxin
Surgery
Neurology
Muscle Spasticity
Anesthesia
Drug Evaluation
Clostridium botulinum
Female
Neurology (clinical)
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 15318249 and 03645134
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Annals of Neurology
- Accession number :
- edsair.doi.dedup.....f468e5535c6b442911b6a286c7755f85