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The effect of earthworm extract on promoting skin wound healing
- Source :
- Bioscience Reports
- Publication Year :
- 2018
- Publisher :
- Portland Press Ltd., 2018.
-
Abstract
- Chronic nonhealing wounds pose a significant challenge to healthcare system because of its tremendous utilization of resources and time to heal. It has a well-deserved reputation for reducing the quality of life for those affected and represent a substantial economic burden to the healthcare system overall. Earthworms are used as a traditional Chinese medicine, and have been applied pharmacologically and clinically since a long time in China. However, there is paucity in data regarding its wound healing effects. Therefore, we investigated the effect of earthworm extract (EE) on skin wound healing process. The obtained data showed that EE has healing effects on local wound of mice. It decreased the wound healing time and reduced the ill-effects of inflammation as determined by macroscopic, histopathologic, hematologic, and immunohistochemistry parameters. The potential mechanism could be accelerated hydroxyproline and transforming growth factor-β secretion—thus increasing the synthesis of collagen, promoting blood capillary, and fibroblast proliferation. It could accelerate the removal of necrotic tissue and foreign bodies by speeding up the generation of interleukin-6, white blood cells, and platelets. It thus enhances immunity, reduces the risk of infection, and promotes wound healing. All in all, the obtained data demonstrated that EE improves quality of healing and could be used as a propitious wound healing agent.
- Subjects :
- 0301 basic medicine
TGF-β
Male
Skin wound
Biophysics
Inflammation
Traditional Chinese medicine
Pharmacology
Complex Mixtures
Biochemistry
03 medical and health sciences
Hydroxyproline
chemistry.chemical_compound
Mice
Hyp
Immunity
medicine
Animals
Medicine, Chinese Traditional
Oligochaeta
Fibroblast
Molecular Biology
Research Articles
Skin
IL-6
Wound Healing
business.industry
Cell Biology
Earthworm extract
030104 developmental biology
medicine.anatomical_structure
chemistry
Wounds and Injuries
Female
medicine.symptom
Wound healing
business
Transforming growth factor
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15734935 and 01448463
- Volume :
- 38
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Bioscience Reports
- Accession number :
- edsair.doi.dedup.....f474f132f421aa961b1dd02a19042b6e