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Anatomical and spiral wave reentry in a simplified model for atrial electrophysiology
- Source :
- Journal of Theoretical Biology. 419:100-107
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- For modeling the propagation of action potentials in the human atria, various models have been developed in the past, which take into account in detail the influence of the numerous ionic currents flowing through the cell membrane. Aiming at a simplified description, the Bueno-Orovio–Cherry–Fenton (BOCF) model for electric wave propagation in the ventricle has been adapted recently to atrial physiology. Here, we study this adapted BOCF (aBOCF) model with respect to its capability to accurately generate spatio-temporal excitation patterns found in anatomical and spiral wave reentry. To this end, we compare results of the aBOCF model with the more detailed one proposed by Courtemanche, Ramirez and Nattel (CRN model). We find that characteristic features of the reentrant excitation patterns seen in the CRN model are well captured by the aBOCF model. This opens the possibility to study origins of atrial fibrillation based on a simplified but still reliable description.
- Subjects :
- 0301 basic medicine
Statistics and Probability
Action Potentials
030204 cardiovascular system & hematology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Heart Conduction System
Reaction–diffusion system
Humans
Computer Simulation
Heart Atria
Atrial electrophysiology
Physics
General Immunology and Microbiology
Applied Mathematics
Models, Cardiovascular
General Medicine
Mechanics
Reentry
Electrophysiological Phenomena
030104 developmental biology
Reentrancy
Electric wave
Modeling and Simulation
Spiral wave
General Agricultural and Biological Sciences
Algorithms
Excitation
Subjects
Details
- ISSN :
- 00225193
- Volume :
- 419
- Database :
- OpenAIRE
- Journal :
- Journal of Theoretical Biology
- Accession number :
- edsair.doi.dedup.....f48bb4c03d70890765469659f3e77fd7