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Regulation of promoter proximal pausing of RNA polymerase II in metazoans
- Source :
- J Mol Biol
- Publication Year :
- 2021
-
Abstract
- Regulation of transcription is a tightly choreographed process. The establishment of RNA polymerase II promoter proximal pausing soon after transcription initiation and the release of Pol II into productive elongation are key regulatory processes that occur in early elongation. We describe the techniques and tools that have become available for the study of promoter proximal pausing and their utility for future experiments. We then provide an overview of the factors and interactions that govern a multipartite pausing process and address emerging questions surrounding the mechanism of RNA polymerase II's subsequent advancement into the gene body. Finally, we address remaining controversies and future areas of study.
- Subjects :
- Transcription, Genetic
RNA polymerase II
Biology
Article
Transcription initiation
03 medical and health sciences
0302 clinical medicine
Structural Biology
Transcription (biology)
Humans
P-TEFb
Promoter Regions, Genetic
Molecular Biology
Gene
030304 developmental biology
0303 health sciences
Mechanism (biology)
DSIF
Cell biology
Gene Expression Regulation
biology.protein
RNA Polymerase II
Transcription factor II D
030217 neurology & neurosurgery
Protein Binding
Transcription Factors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- J Mol Biol
- Accession number :
- edsair.doi.dedup.....f4915a9e744be1dd206ec1eb00785226