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Salvage Surgery Compared to Surgery After Induction Chemoradiation Therapy for Advanced Lung Cancer
- Source :
- The Annals of Thoracic Surgery. 114:2087-2092
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Background Salvage surgery is performed for selected patients with relapses of locally advanced lung cancer after definitive chemoradiation therapy (CRT), and seems to be effective. To date, the feasibility of such salvage surgery, particularly anatomical pulmonary resection, has not been fully evaluated. To assess the feasibility of salvage surgery after definitive CRT, we compared clinical outcomes of surgery after definitive CRT to those of surgery after induction CRT. Methods Medical records of patients who underwent surgery from January 2000 to January 2018 were reviewed. We compared patients with salvage anatomical pulmonary resection after definitive CRT to patients with surgery after induction CRT in terms of perioperative and long-term outcomes. Results Twenty-three patients underwent salvage surgery after definitive CRT for locally advanced lung cancer (salvage group) and 36 underwent surgery after induction CRT for cN2-stage III non-small cell lung cancer (induction CRT group). The surgical procedures in the salvage group were 2 segmentectomies, 13 lobectomies, 1 bi-lobectomy and 7 pneumonectomies, and those in the induction CRT group were 34 lobectomies and 2 bi-lobectomies. There was no 30-day or 90-day mortality in either group. The 5-year overall survival was 44.7% for the salvage group and 58.6% for the induction CRT group. The 5-year progression-free interval was 42.2% for the salvage group and 47.7% for the induction CRT group. Conclusions Salvage anatomical pulmonary resection after definitive CRT for locally advanced lung cancer is feasible with acceptable morbidity and prognosis in highly selected patients.
- Subjects :
- Pulmonary and Respiratory Medicine
medicine.medical_specialty
Lung Neoplasms
genetic structures
Locally advanced
Carcinoma, Non-Small-Cell Lung
medicine
Humans
cardiovascular diseases
Lung cancer
Neoplasm Staging
Retrospective Studies
Salvage Therapy
business.industry
Medical record
Chemoradiotherapy
Perioperative
Surgical procedures
medicine.disease
Surgery
Treatment Outcome
cardiovascular system
Salvage surgery
Non small cell
Neoplasm Recurrence, Local
Pulmonary resection
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 00034975
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- The Annals of Thoracic Surgery
- Accession number :
- edsair.doi.dedup.....f497e0cd68db1b549ec45c3e73141922