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Apolipoprotein E gene polymorphism and left ventricular function in Iranian patients with thalassemia major
- Source :
- Haematologica. 92(2)
- Publication Year :
- 2007
-
Abstract
- Left ventricular (LV) failure is the main cause of death in thalassemia. Iron overload in patients with thalassemia leads to the formation of oxygen free radicals. Of the various apolipoprotein E (apoE) alleles, apoE4 is the least efficient in conditions of oxidative stress in comparison with apoE2 and apoE3. Our results showed that apoE4 is a genetic risk factor for LV dysfunction in thalassemia.
- Subjects :
- Apolipoprotein E
Apolipoprotein E Gene
Adult
Male
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Adolescent
Apolipoprotein E2
Thalassemia
Apolipoprotein E4
Apolipoprotein E3
Iran
medicine.disease_cause
Ventricular Dysfunction, Left
Apolipoproteins E
Risk Factors
hemic and lymphatic diseases
Internal medicine
Medicine
Humans
In patient
Allele
Child
Cause of death
Genetics
Polymorphism, Genetic
Ventricular function
business.industry
beta-Thalassemia
Hematology
medicine.disease
Cardiology
lipids (amino acids, peptides, and proteins)
Female
business
Oxidative stress
Subjects
Details
- ISSN :
- 15928721
- Volume :
- 92
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Haematologica
- Accession number :
- edsair.doi.dedup.....f49cdac21a7d5b7bb74b9a309d0f8879