Back to Search
Start Over
The Emerging Role of MicroRNAs in NAFLD: Highlight of MicroRNA-29a in Modulating Oxidative Stress, Inflammation, and Beyond
- Source :
- Cells, Vol 9, Iss 1041, p 1041 (2020), Cells
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease and ranges from steatosis to steatohepatitis and to liver fibrosis. Lipotoxicity in hepatocytes, elevated oxidative stress and the activation of proinflammatory mediators of Kupffer cells, and fibrogenic pathways of activated hepatic stellate cells can contribute to the development of NAFLD. MicroRNAs (miRs) play a crucial role in the dysregulated metabolism and inflammatory signaling connected with NAFLD and its progression towards more severe stages. Of note, the protective effect of non-coding miR-29a on liver damage and its versatile action on epigenetic activity, mitochondrial homeostasis and immunomodulation may improve our perception of the pathogenesis of NAFLD. Herein, we review the biological functions of critical miRs in NAFLD, as well as highlight the emerging role of miR-29a in therapeutic application and the recent advances in molecular mechanisms underlying its liver protective effect.
- Subjects :
- 0301 basic medicine
Inflammation
Review
Chronic liver disease
medicine.disease_cause
digestive system
Proinflammatory cytokine
Epigenesis, Genetic
03 medical and health sciences
0302 clinical medicine
Non-alcoholic Fatty Liver Disease
NAFLD
medicine
Humans
lcsh:QH301-705.5
liver fibrosis
business.industry
Fatty liver
NASH
Genetic Pleiotropy
General Medicine
medicine.disease
digestive system diseases
microRNAs
mitochondria
Oxidative Stress
030104 developmental biology
Lipotoxicity
lcsh:Biology (General)
030220 oncology & carcinogenesis
Cancer research
Hepatic stellate cell
medicine.symptom
Steatohepatitis
business
Oxidative stress
microRNA-29a
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 9
- Issue :
- 1041
- Database :
- OpenAIRE
- Journal :
- Cells
- Accession number :
- edsair.doi.dedup.....f4a9cef3b2a22f07d4327eb359dd5516