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Systemic lupus erythematosus, antiphospholipid syndrome and Hashimoto thyroiditis occurring in a patient with Niemann-Pick disease: a second case
- Source :
- Pan African Medical Journal; Vol. 36 No. 1 (2020), The Pan African Medical Journal
- Publication Year :
- 2020
- Publisher :
- Pan African Medical Journal, 2020.
-
Abstract
- Lysosomial diseases and autoimmune diseases are systemic disorders. Their clinical manifestations can overlap with the broad spectrum of one another. Their association has been rarely reported. We report a new case of systemic lupus erythematous (SLE) associated to antiphospholipid syndrome (APS) and Hashimoto thyroiditis occurring in Niemann-Pick disease (NPD) type B patient. A 42-year-old woman with a familial history of NPD was diagnosed with a NPD type B at the age of ten. Twenty years later (2008), she complained of inflammatory arthralgia with acute dyspnea. She was diagnosed with SLE (according to ACR criteria) and Hashimoto disease with positive IgG anti-cardiolipin and IgA anti-beta2 glycoprotein. In 2018, she presented a left segmental pulmonary embolism. Antiphospholipid syndrome was retained. She was treated with steroids, hydroxychloroquine, anticoagulation therapy and levothyroxine. Her SLE treatment was re-enforced by cyclophosphamide because of corticosteroid dependence and recurrent hemolytic crises.
- Subjects :
- Hashimoto thyroiditis
medicine.medical_specialty
Cyclophosphamide
medicine.drug_class
030231 tropical medicine
Levothyroxine
Case Report
Disease
systemic lupus erythematous
03 medical and health sciences
0302 clinical medicine
immune system diseases
Antiphospholipid syndrome
medicine
Hashimoto Disease
030212 general & internal medicine
skin and connective tissue diseases
business.industry
Hydroxychloroquine
General Medicine
medicine.disease
Dermatology
Pulmonary embolism
Corticosteroid
Niemann-Pick disease
antiphospholipid syndrome
business
medicine.drug
Subjects
Details
- ISSN :
- 19378688
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Pan African Medical Journal
- Accession number :
- edsair.doi.dedup.....f4c637f28de0772b5e6295f3813d682e