Back to Search
Start Over
Patients with High-Grade Gliomas Harboring Deletions of Chromosomes 9p and 10q Benefit from Temozolomide Treatment
- Source :
- Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 10, Pp 883-893 (2005)
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Surgical cure of glioblastomas is virtually impossible and their clinical course is mainly determined by the biologic behavior of the tumor cells and their response to radiation and chemotherapy. We investigated whether response to temozolomide (TMZ) chemotherapy differs in subsets of malignant glioblastomas defined by genetic lesions. Eighty patients with newly diagnosed glioblastoma were analyzed with comparative genomic hybridization and loss of heterozygosity. All patients underwent radical resection. Fifty patients received TMZ after radiotherapy (TMZ group) and 30 patients received radiotherapy alone (RT group). The most common aberrations detected were gains of parts of chromosome 7 and losses of 10% 9p, or 13q. The spectrum of genetic aberrations did not differ between the TMZ and RT groups. Patients treated with TMZ showed significantly better survival than patients treated with radiotherapy alone (19.5 vs 9.3 months). Genomic deletions on chromosomes 9 and 10 are typical for glioblastoma and associated with poor prognosis. However, patients with these aberrations benefited significantly from TMZ in univariate analysis. In multivariate analysis, this effect was pronounced for 9p deletion and for elderly patients with 10q deletions, respectively. This study demonstrates that molecular genetic and cytogenetic analyses potentially predict responses to chemotherapy in patients with newly diagnosed glioblastomas.
- Subjects :
- Oncology
Male
Cancer Research
Pathology
Time Factors
Kip
medicine.medical_treatment
Loss of Heterozygosity
LOH
Chromosome 7 (human)
Brain Neoplasms
Age Factors
Nucleic Acid Hybridization
Glioma
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Dacarbazine
Treatment Outcome
Paraffin
Female
Chromosome Deletion
Chromosomes, Human, Pair 9
medicine.drug
Research Article
Adult
Genetic Markers
medicine.medical_specialty
Biology
lcsh:RC254-282
survival
Chromosomes
glioblastoma multiforme
Cytogenetics
Sex Factors
Internal medicine
medicine
Temozolomide
Humans
Antineoplastic Agents, Alkylating
CGH
Aged
Proportional Hazards Models
Chemotherapy
Models, Genetic
Chromosomes, Human, Pair 10
medicine.disease
Radiation therapy
Multivariate Analysis
TMZ
Glioblastoma
Gene Deletion
Comparative genomic hybridization
Microsatellite Repeats
Subjects
Details
- ISSN :
- 14765586
- Volume :
- 7
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Neoplasia
- Accession number :
- edsair.doi.dedup.....f4d38da507b14d9ca7ed6a49175e710f
- Full Text :
- https://doi.org/10.1593/neo.05307