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Effect of Polycyclic Aromatic Hydrocarbons Exposure on Sperm DNA in Idiopathic Male Infertility
Effect of Polycyclic Aromatic Hydrocarbons Exposure on Sperm DNA in Idiopathic Male Infertility
- Source :
- Journal of Health & Pollution, Journal of Health and Pollution, Vol 9, Iss 21, Pp 1-11 (2019)
- Publication Year :
- 2019
- Publisher :
- Environmental Health Perspectives, 2019.
-
Abstract
- Background. Biological mechanisms contribute to the relationship between polycyclic aromatic hydrocarbon (PAH) exposure and infertility in males by altering semen quality. Objectives. The aim of the present study was to evaluate the impact of PAHs on male infertility using the sperm chromatin dispersion test (Halo sperm assay). Methods. Sixty-six (66) infertile males under 45 years of age were examined for the determination of urinary metabolite and oxidative stress by measuring lipid peroxidation and antioxidant activity of glutathione and glutathione-s-transferase, as well as hormonal activity of follicle stimulating hormone (FSH), testosterone and prolactin and semen quality. Results. There was an increased level of urinary metabolite of 1-hydroxy pyrene, 1-hydroxy naphthalene and 2-hydroxy naphthalene in the urine of the infertile group. In addition, elevated concentrations of malondialdehyde coincided with a decreased level of antioxidants, leading to oxidative stress in the infertile group. Semen samples showed 30% sperm deoxyribonucleic acid (DNA) fragmentation. Conclusions. The data provide strong evidence of a statistical threshold for semen samples containing 30% sperm DNA fragmentation resulting in a reduced level of pregnancy success. Participant consent. Obtained Ethics Approval. Study approval was given by the ethics committee of Alexandria University (United States Department of Health and Human Services, institutional review board registration (IRB), IORG0008812 Medical Research Institute, expires 4/8/2019, OMB No: 0990-0279). Competing Interests. The authors declare no competing financial interests.
- Subjects :
- Infertility
010504 meteorology & atmospheric sciences
Health, Toxicology and Mutagenesis
Polycyclic aromatic hydrocarbon
Semen
010501 environmental sciences
Biology
01 natural sciences
lcsh:TD1-1066
Male infertility
Andrology
Semen quality
chemistry.chemical_compound
medicine
sperm DNA fragmentation
lcsh:Environmental technology. Sanitary engineering
0105 earth and related environmental sciences
chemistry.chemical_classification
Research
Public Health, Environmental and Occupational Health
urinary metabolite
semen
PAH
medicine.disease
Pollution
Sperm
chemistry
DNA fragmentation
DNA
Subjects
Details
- ISSN :
- 21569614
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of Health and Pollution
- Accession number :
- edsair.doi.dedup.....f4d3bc97e2b550270ab731645b7e78c8
- Full Text :
- https://doi.org/10.5696/2156-9614-9.21.190309