Back to Search
Start Over
Association between the Adherence to the International Guidelines for Cancer Prevention and Mammographic Density
- Source :
- Repisalud, Instituto de Salud Carlos III (ISCIII), PLoS ONE, PLoS ONE, Vol 10, Iss 7, p e0132684 (2015), PLoS One, r-FISABIO. Repositorio Institucional de Producción Científica, instname, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
- Publication Year :
- 2015
- Publisher :
- Public Library of Science (PLOS), 2015.
-
Abstract
- Introduction Mammographic density (MD) is considered a strong predictor of Breast Cancer (BC). The objective of the present study is to explore the association between MD and the compliance with the World Cancer Research Fund and the American Institute for Cancer Research (WCRF/AICR) recommendations for cancer prevention. Methods Data of 3584 women attending screening from a population-based multicenter cross-sectional study (DDM-Spain) collected from October 7, 2007 through July 14, 2008, was used to calculate a score that measures the level of compliance with the WCRF/AICR recommendations: R1)Maintain adequate body weight; R2)Be physically active; 3R)Limit the intake of high density foods; R4)Eat mostly plant foods; R5)Limit the intake of animal foods; R6)Limit alcohol intake; R7)Limit salt and salt preserved food intake; R8)Meet nutritional needs through diet. The association between the score and MD (assessed by a single radiologist using a semi-quantitative scale) was evaluated using ordinal logistic models with random center-specific intercepts adjusted for the main determinants of MD. Stratified analyses by menopausal status and smoking status were also carried out. Results A higher compliance with the WCRF/AICR recommendations was associated with lower MD (OR1-unit increase = 0.93 95%CI:0.86;0.99). The association was stronger in postmenopausal women (OR = 0.91 95%CI:0.84;0.99) and nonsmokers (OR = 0.87;95%CI:0.80;0.96 for nonsmokers, OR = 1.01 95%CI:0.91;1.12 for smokers, P-interaction = 0.042). Among nonsmokers, maintaining adequate body weight (OR = 0.81 95%CI:0.65;1.01), practicing physical activity (OR = 0.68 95%CI:0.48;0.96) and moderating the intake of high-density foods (OR = 0.58 95%CI:0.40;0.86) and alcoholic beverages (OR = 0.76 95%CI:0.55;1.05) were the recommendations showing the strongest associations with MD. Conclusions postmenopausal women and non-smokers with greater compliance with the WCRF/AICR guidelines have lower MD. These results may provide guidance to design specific recommendations for screening attendants with high MD and therefore at higher risk of developing BC.<br />This study was supported by FIS PI060386 FIS (Health Research Fund) Research Grant; EC11-273 Research Grant from the Spanish Ministy of Health; CD110/00018 FIS Sara Borrell contract; FECMA 485 EPY 1170-10 grant from the Spanish Federation of Breast Cancer Patients.
- Subjects :
- medicine.medical_specialty
cumplimiento del paciente
Cross-sectional study
humanos
cribado sistemático
Population
Physical activity
lcsh:Medicine
neoplasias de la mama
Breast Neoplasms
Breast cancer
Risk Factors
Environmental health
factores de riesgo
Medicine
Humans
Mass Screening
lcsh:Science
education
Mammary Glands, Human
Mass screening
Breast Density
Gynecology
education.field_of_study
Multidisciplinary
Cancer prevention
business.industry
lcsh:R
MAMMOGRAPHIC DENSITY
medicine.disease
Postmenopause
Cross-Sectional Studies
Spain
postmenopausia
Patient Compliance
lcsh:Q
Smoking status
Female
business
estudios transversales
Research Article
Subjects
Details
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- Repisalud, Instituto de Salud Carlos III (ISCIII), PLoS ONE, PLoS ONE, Vol 10, Iss 7, p e0132684 (2015), PLoS One, r-FISABIO. Repositorio Institucional de Producción Científica, instname, Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid, Consejería de Sanidad de la Comunidad de Madrid, r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
- Accession number :
- edsair.doi.dedup.....f4d5bb0d5d47aec04010e078af49f8e9