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Antiviral treatment with pegylated interferon and clinical outcomes in a cohort of immigrants patients affected by hepatitis delta: A retrospective analysis
- Source :
- Journal of medical virology. 91(7)
- Publication Year :
- 2018
-
Abstract
- Chronic hepatitis delta (CHD) is the most severe chronic hepatitis, with no satisfactory treatment options and severe clinical outcomes. This infection is frequent in the migrant subjects from endemic areas, especially from Africa and East-Europe. The pegylated (PEG)-interferon α (IFN) is limited by side effects and poor response. In this retrospective analysis, we reported our experience of treatment with PEG-IFN in a cohort of immigrant patients affected by CHD. We evaluated the virological responses are as follows: complete response (CR; clearance of hepatitis B surface antigen [HBsAg] and hepatitis D virus [HDV]-RNA), partial response (PR; HBsAg clearance with HDV-RNA+), and null response (NR; HBsAg and HDV-RNA+). Clinical outcomes were clinical stabilization, disease progression, hepatic decompensation, hepatocellular carcinoma (HCC), death, and liver transplantation. Forty-six patients were included. At the end of treatment (ET), 11 patients gained a CR (23.9%), 10 were PR (21.7%), and 16 were NR (34.8%). After 1 year, 10 remained with CR (21.7%), after 2 years, 9 (19.5%), and at 3 years, 8 (17.4%). Relapse rate was 2.2%, 4.4%, and 6.5% at year 1, 2, and 3, respectively. Favorable factors were CR at the ET (odds ratio [OR] = 4.559, 95% confidence interval [CI]: 2.219-7.116; P = 0.003), PEG-IFN course greater than 1 (OR = 1.240, 95% CI: 0.998-4.839; P = 0.012), prolonged treatment (OR = 1.276, 95% CI: 0.816-3.108; P = 0.018), quantitative hepatitis B surface antigen (qHBsAg) decline at 12 weeks greater than 0.5 log IU/mL (OR = 4.816, 95% CI: 2.190-8.194; P
- Subjects :
- Adult
Male
medicine.medical_specialty
HBsAg
Cirrhosis
Hepatitis D, Chronic
medicine.medical_treatment
Emigrants and Immigrants
Liver transplantation
Gastroenterology
Antiviral Agents
Polyethylene Glycols
03 medical and health sciences
0302 clinical medicine
Pegylated interferon
Recurrence
Virology
Internal medicine
clinical outcomes
hepatitis D virus
immigrants
pegylated interferon
quantitative hepatitis B surface antigen
Infectious Diseases
medicine
Humans
030212 general & internal medicine
Retrospective Studies
business.industry
Interferon-alpha
Odds ratio
medicine.disease
Treatment Outcome
Italy
Hepatocellular carcinoma
Cohort
030211 gastroenterology & hepatology
Female
Hepatitis D virus
business
medicine.drug
Subjects
Details
- ISSN :
- 10969071
- Volume :
- 91
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of medical virology
- Accession number :
- edsair.doi.dedup.....f4e917775349dc1aeb2cc7213ef69997