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Synthetic mycomelanin thin films as emergent bio-inspired interfaces controlling the fate of embryonic stem cells
- Source :
- Journal of Materials Chemistry B 8 (2020): 4412–4418. doi:10.1039/d0tb00623h, info:cnr-pdr/source/autori:Manini, Paola; Lucci, Valeria; Lino, Valeria; Sartini, Stefania; Rossella, Francesco; Falco, Geppino; Chiappe, Cinzia; d'Ischia, Marco/titolo:Synthetic mycomelanin thin films as emergent bio-inspired interfaces controlling the fate of embryonic stem cells/doi:10.1039%2Fd0tb00623h/rivista:Journal of Materials Chemistry B/anno:2020/pagina_da:4412/pagina_a:4418/intervallo_pagine:4412–4418/volume:8
- Publication Year :
- 2020
-
Abstract
- The fungal pathways of melanin synthesis have so far been little considered as a source of bio-inspiration in the field of functional materials, despite the interesting properties exhibited by Ascomycetes melanins from 1,8-dihydroxynaphthalene (1,8-DHN), including the ability to shield organisms from ionizing radiation. Herein, the processing techniques and characterizations of mycomelanin thin films obtained from the solid state polymerization of 1,8-DHN is reported for the first time. Overall, the results highlighted the role of synthetic mycomelanin thin films as a prototype of next generation bioinspired interfaces featuring high structural regularity and ultrasmooth morphology, high robustness against peroxidative bleaching and adhesion under water conditions, good biocompatibility and unprecedented effects in inducing the spontaneous differentiation of embryonic stem cells prevalently towards the endodermal lineages in the absence of added factors. These data open up new avenues towards the applications of this biomaterial in the fields of tissue engineering and regenerative medicine.
- Subjects :
- Materials science
Biocompatibility
Biomedical Engineering
Cell Culture Techniques
Nanotechnology
Biocompatible Materials
Naphthols
Regenerative medicine
Polymerization
Mice
Tissue engineering
Ascomycota
Animals
Humans
General Materials Science
Thin film
Embryonic Stem Cells
Melanins
Tissue Engineering
Biomaterial
Cell Differentiation
General Chemistry
General Medicine
Adhesion
Embryonic stem cell
HEK293 Cells
melanins, thin films, biointerface, stem cells
Synthetic Mycomelanin Thin Films
Embryonic
Cells
Structural regularity
Subjects
Details
- ISSN :
- 20507518
- Volume :
- 8
- Issue :
- 20
- Database :
- OpenAIRE
- Journal :
- Journal of materials chemistry. B
- Accession number :
- edsair.doi.dedup.....f4fce0d04f5dc9838f5a6af928c4e9cd