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New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases
- Source :
- Journal of cellular biochemistry. 120(6)
- Publication Year :
- 2018
-
Abstract
- Neurodegenerative diseases (NDs) are a diversity of neurological disorders characterized by the progressive degeneration of the structure and function of the central nervous system (CNS). The most common NDs are Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Recently, many studies have investigated associations between common NDs with noncoding RNAs (ncRNAs) molecules. ncRNAs are regulatory molecules in the normal functioning of the CNS. Two of the most important ncRNAs are microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). These types of ncRNAs are involved in different biological processes including brain development, maturation, differentiation, neuronal cell specification, neurogenesis, and neurotransmission. Increasing data has demonstrated that miRNAs and lncRNAs have strong correlations with the development of NDs, particularly gene expression. Besides, ncRNAs can be introduced as new biomarkers for diagnosis and prognosis of NDs. Hence, in this review, we summarized the involvement of various miRNAs and lncRNAs in most common NDs followed by a correlation of ncRNAs dysregulation with the AD, PD, and HD.
- Subjects :
- 0301 basic medicine
Genetic Markers
Central nervous system
Disease
Biology
Biochemistry
03 medical and health sciences
0302 clinical medicine
Gene expression
microRNA
medicine
Humans
Genetic Predisposition to Disease
Molecular Biology
Neurogenesis
Neurodegenerative Diseases
Cell Biology
Long non-coding RNA
Normal functioning
MicroRNAs
030104 developmental biology
medicine.anatomical_structure
Gene Expression Regulation
030220 oncology & carcinogenesis
Biomarker (medicine)
RNA, Long Noncoding
Neuroscience
Subjects
Details
- ISSN :
- 10974644
- Volume :
- 120
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of cellular biochemistry
- Accession number :
- edsair.doi.dedup.....f50ae69117f2a919a23659cc2f9c3344