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Association between Helicobacter pylori infection and mild cognitive impairment

Association between Helicobacter pylori infection and mild cognitive impairment

Authors :
Marina Boziki
Nikolaos Kapetanakis
Emmanuel Gavalas
Ioannis Venizelos
Christos Stergiopoulos
Dimitrios Chatzopoulos
Christos Zavos
Magda Tsolaki
Jannis Kountouras
Source :
European Journal of Neurology. 14:976-982
Publication Year :
2007
Publisher :
Wiley, 2007.

Abstract

The association of Helicobacter pylori infection and Alzheimer's disease (AD) has recently been addressed, but no relative data exist regarding mild cognitive impairment (MCI), a prodromal phase of AD. The aim of this prospective study was to evaluate H. pylori infection, by histology in a Greek MCI cohort. Sixty-three consecutive patients with amnestic MCI and 35 normal controls underwent upper gastrointestinal endoscopy, histologic and serological examinations. The prevalence of H. pylori infection was 88.9% (56/63) in MCI patients and 48.6% (17/35) in anaemic controls, as confirmed by biopsy (P < 0.001, odds ratio: 8.47, 95% CI: 3.03-23.67). Mean serum anti-H. pylori IgG concentration and plasma total homocysteine (Hcy) titre were higher in MCI patients than controls (74.86 +/- 57.22 vs. 17.37 +/- 9.30 U/ml; and 16.03 +/- 4.28 vs. 13.5 +/- 1.20 micromol/l; P < 0.001 and P = 0.015, respectively). When compared with the anaemic participants, MCI patients exhibited more often multifocal (body and antral) gastritis (92.1% vs. 68.6%; P = 0.03); in H. pylori positive MCI patients cognitive state correlated with serum anti-H. pylori IgG concentration. In conclusion, H. pylori prevalence was significantly higher in MCI patients than controls. This infection might contribute, at least in part, to the pathophysiology of MCI, possibly through induction of chronic atrophic gastritis and elevated Hcy consequences.

Details

ISSN :
14681331 and 13515101
Volume :
14
Database :
OpenAIRE
Journal :
European Journal of Neurology
Accession number :
edsair.doi.dedup.....f50e762ca2d7b581be4a4f04b90ef9a2
Full Text :
https://doi.org/10.1111/j.1468-1331.2007.01827.x