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Therapy of endodermal sinus tumor of the ovary
- Source :
- American Journal of Obstetrics and Gynecology. 135:447-451
- Publication Year :
- 1979
- Publisher :
- Elsevier BV, 1979.
-
Abstract
- Endodermal sinus tumor of the ovary can be differentiated histologically and immunohistochemically from ovarian embryonal cell carcinoma. A case report of a patient with endodermal sinus tumor is presented in which a long-term remission was achieved by unilateral adnexectomy and combination chemotherapy. Review of the current literature indicates that tumor removal followed by combination chemotherapy with vincristine, actinomycin D, and cyclophosphamide is the most effective method of therapy for this highly malignant ovarian neoplasm. The addition of hysterectomy with contralateral ovariectomy or radiation therapy does not appear to significantly improve the survival of patients with this tumor. Serial plasma determinations of alpha fetoprotein provide biochemical monitoring of response to therapy and may be useful in predicting occult tumor recurrence.
- Subjects :
- Adult
Pathology
medicine.medical_specialty
Vincristine
Adolescent
Cyclophosphamide
medicine.medical_treatment
Ovary
Cervix Uteri
Dysgerminoma
Drug Administration Schedule
medicine
Humans
Child
Ovarian Neoplasms
Hysterectomy
Malignant Ovarian Neoplasm
business.industry
Obstetrics and Gynecology
Combination chemotherapy
Endodermal sinus tumor
medicine.disease
Radiation therapy
medicine.anatomical_structure
Dactinomycin
Drug Therapy, Combination
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 00029378
- Volume :
- 135
- Database :
- OpenAIRE
- Journal :
- American Journal of Obstetrics and Gynecology
- Accession number :
- edsair.doi.dedup.....f51cf6606ea1687538016caf0d703850