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Comparative study of ROR2 and WNT5a expression in squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder
- Source :
- World Journal of Gastroenterology
- Publication Year :
- 2017
- Publisher :
- Baishideng Publishing Group Inc., 2017.
-
Abstract
- AIM To investigate the expression and clinical pathological significance of ROR2 and WNT5a in gallbladder squamous/adenosquamous carcinoma (SC/ASC) and adenocarcinoma (AC). METHODS EnVision immunohistochemistry was used to stain for ROR2 and WNT5a in 46 SC/ASC patients and 80 AC patients. RESULTS Poorly differentiated AC among AC patients aged > 45 years were significantly more frequent compared with SC/ASC patients, while tumors with a maximal diameter > 3 cm in the SC/ASC group were significantly more frequent compared with the AC group. Positive ROR2 and WNT5a expression was significantly lower in SC/ASC or AC with a maximal mass diameter ≤ 3 cm, a TNM stage of I + II, no lymph node metastasis, no surrounding invasion, and radical resection than in patients with a maximal mass diameter > 3 cm, TNM stage IV, lymph node metastasis, surrounding invasion, and no resection. Positive ROR2 expression in patients with highly differentiated SC/ASC was significantly lower than in patients with poorly differentiated SC/ASC. Positive ROR2 and WNT5a expression levels in highly differentiated AC were significantly lower than in poorly differentiated AC. Kaplan-Meier survival analysis showed that differentiation degree, maximal mass diameter, TNM stage, lymph node metastasis, surrounding invasion, surgical procedure and the ROR2 and WNT5a expression levels were closely related to average survival of SC/ASC or AC. The survival of SC/ASC or AC patients with positive expression of ROR2 and WNT5a was significantly shorter than that of patients with negative expression results. Cox multivariate analysis revealed that poor differentiation, a maximal diameter of the mass ≥ 3 cm, TNM stage III or IV, lymph node metastasis, surrounding invasion, unresected surgery and positive ROR2 or WNT5a expression in the SC/ASC or AC patients were negatively correlated with the postoperative survival rate and positively correlated with mortality, which are risk factors and independent prognostic predictors. CONCLUSION SC/ASC or AC patients with positive ROR2 or WNT5a expression generally have a poor prognosis.
- Subjects :
- Male
0301 basic medicine
Oncology
Pathology
Time Factors
Clinical Trials Study
Kaplan-Meier Estimate
0302 clinical medicine
Risk Factors
Gallbladder adenosquamous carcinoma
WNT5a
ROR2
Aged, 80 and over
Gallbladder Adenosquamous Carcinoma
Gallbladder adenocarcinoma
Gastroenterology
Gallbladder squamous carcinoma
Cell Differentiation
General Medicine
Middle Aged
Immunohistochemistry
Up-Regulation
WNT5A
Treatment Outcome
medicine.anatomical_structure
030220 oncology & carcinogenesis
embryonic structures
Adenocarcinoma
Female
Gallbladder Neoplasms
Adult
China
medicine.medical_specialty
Adenosquamous carcinoma
Receptor Tyrosine Kinase-like Orphan Receptors
Wnt-5a Protein
Carcinoma, Adenosquamous
03 medical and health sciences
Internal medicine
Biomarkers, Tumor
medicine
Humans
Neoplasm Invasiveness
Aged
Neoplasm Staging
Proportional Hazards Models
Chi-Square Distribution
business.industry
Gallbladder
medicine.disease
digestive system diseases
body regions
stomatognathic diseases
030104 developmental biology
Multivariate Analysis
sense organs
Gallbladder Neoplasm
business
Subjects
Details
- ISSN :
- 10079327
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- World Journal of Gastroenterology
- Accession number :
- edsair.doi.dedup.....f5222bad92492ebf6913789cc134aa0e