Summaries of Key Journal Articles

Summary written by: Fred Morady, MD, FACC Large Scale Replication and Meta-Analysis ofVariants on Chromosome 4q25 Associated WithAtrial Fibrillation Kaab S, Darbar D, van Noord C, et al. Eur Heart J 2009;Jan 13:[Epub ahead of print].Study Design: Is the association between genetic variation onchromosome 4q25 and atrial fibrillation (AF) reproduciblewhen applied to other cohorts? Methods: This association was analyzed in four independentcohorts, including 12,173 patients. The Framingham HeartStudy and Rotterdam Study are community-based longitudi-nal studies. The Vanderbilt AF Registry and German AFNetwork (AFNet) are case-control studies. Journal of the American College of Cardiology© 2009 by the American College of Cardiology FoundationPublished by Elsevier Inc.Vol. 53, No. 9, 2009ISSN 0735-1097/09/$36.00doi:10.1016/j.jacc.2009.02.002 SCANNING THE LITERATURE Summaries of Key Journal Articles Kim A. Eagle, MD, FACC, Editor-in-Chief, Journal Scan, Ann Arbor, MI Christopher P. Cannon, MD, FACC, Editor-in-Chief, Cardiosource