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Novelty preference predicts place preference conditioning to morphine and its oral consumption in rats
- Source :
- Pharmacology Biochemistry and Behavior / Pharmacology Biochemistry and Behaviour, Pharmacology Biochemistry and Behavior / Pharmacology Biochemistry and Behaviour, 2006, 84, pp.43-50
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- Sensation seeking is frequently observed among drug addicts. This behaviour has been modelled in non-primate animals as novelty seeking. We previously determined that novelty preference did not predict amphetamine-induced place conditioning but was positively correlated with the consumption of a low concentrated amphetamine solution. Here, we studied the relationship between novelty seeking and the vulnerability to rewarding and reinforcing effects of morphine. Wistar rats were selected according to their novelty preference. In this model, animals have free choice between a new compartment and a "familiar" compartment to which they were previously exposed during two 30-min sessions, 24 h apart. We measured oral morphine consumption when this drug was presented in tap water (25 or 50 mg/l) in free choice with water or when it was presented (50 mg/l) in a 5% (w/v) sucrose solution in free choice with a sucrose solution. The oral consumption of quinine was also measured. The rewarding effect of morphine (1.25 and 5 mg/kg; i.p.) was determined in a conditioned place preference paradigm. Whereas high and low novelty seekers did not differ in reactivity to the aversive taste of quinine, preference for novelty was associated with a greater oral morphine consumption as well as an increased conditioned place preference induced by the 5 mg/kg dose of morphine. The present results support the hypothesis that novelty preference predisposes to drug abuse.
- Subjects :
- Male
medicine.medical_specialty
Clinical Biochemistry
Administration, Oral
Toxicology
Biochemistry
Behavioral Neuroscience
Internal medicine
medicine
Animals
Sensation seeking
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Rats, Wistar
Amphetamine
Biological Psychiatry
ComputingMilieux_MISCELLANEOUS
Pharmacology
Behavior, Animal
Morphine
Quinine
Novelty seeking
Novelty
Preference
Conditioned place preference
Rats
Endocrinology
Anesthesia
Conditioning
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Psychology
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Pharmacology Biochemistry and Behavior / Pharmacology Biochemistry and Behaviour, Pharmacology Biochemistry and Behavior / Pharmacology Biochemistry and Behaviour, 2006, 84, pp.43-50
- Accession number :
- edsair.doi.dedup.....f53782ea805e448c9dd05c02d6a4a9e0