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Positive outcome after preimplantation diagnosis of aneuploidy in human embryos *
- Source :
- Human Reproduction. 14:2191-2199
- Publication Year :
- 1999
- Publisher :
- Oxford University Press (OUP), 1999.
-
Abstract
- usromosomal abnormalities are responsible for a great deal of embryo wastage, which is reflected, at least partially, in decreased implantation and increased miscarriage in older women. To address this problem the transfer of only chromosomally normal embryos previously selected by preimplantation genetic diagnosis (PGD) has been proposed. We designed a multi-centre in-vitro fertilization (IVF) study to compare controls and a test group that underwent embryo biopsy and PGD for aneuploidy. Patients were matched retrospectively, but blindly, for average maternal age, number of previous IVF cycles, duration of stimulation, oestradiol concentrations on day +1, and average mature follicles. All these parameters were similar in test and control groups. Only embryos classified as normal for those chromosomes were transferred after PGD. The results showed that the rates of fetal heart beat (FHB)/embryo transferred between the control and test groups were similar. However, spontaneous abortions, measured as FHB aborted/FHB detected, decreased after PGD (P0.05), and ongoing pregnancies and delivered babies increased (P0.05) in the PGD group of patients. Two conclusions were obtained: (i) PGD of aneuploidy reduced embryo loss after implantation; (ii) implantation rates were not significantly improved, but the proportion of ongoing and delivered babies was increased.
- Subjects :
- medicine.medical_specialty
Embryonic Development
Aneuploidy
Fertilization in Vitro
Biology
Miscarriage
Andrology
Pregnancy
Prenatal Diagnosis
medicine
Humans
Embryo Implantation
Gynecology
Estradiol
Rehabilitation
Pregnancy Outcome
Obstetrics and Gynecology
Embryo
Heart Rate, Fetal
Embryo Transfer
medicine.disease
Embryo transfer
Reproductive Medicine
embryonic structures
Chromosome abnormality
Gestation
Female
Trisomy
Maternal Age
Subjects
Details
- ISSN :
- 14602350 and 02681161
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Human Reproduction
- Accession number :
- edsair.doi.dedup.....f53c25c769b413a279d110ee48dbbfb6