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Mg2+ Transporters in Digestive Cancers
- Source :
- Nutrients, Vol 13, Iss 210, p 210 (2021), Nutrients, Nutrients, MDPI, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩, Nutrients, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters’ expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.
- Subjects :
- 0301 basic medicine
Cell physiology
[SDV]Life Sciences [q-bio]
overall survival
Cell
CBS domain
[SDV.CAN]Life Sciences [q-bio]/Cancer
lcsh:TX341-641
Review
Biology
03 medical and health sciences
0302 clinical medicine
[SDV.CAN] Life Sciences [q-bio]/Cancer
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
TRPM6
medicine
Animals
Homeostasis
Humans
Magnesium
Cation Transport Proteins
Gastrointestinal Neoplasms
Ion Transport
Nutrition and Dietetics
digestive cancers
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Transporter
TCGA
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
3. Good health
Cell biology
Solute carrier family
Gene Expression Regulation, Neoplastic
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Cancer cell
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Disease Susceptibility
lcsh:Nutrition. Foods and food supply
Biomarkers
Cation transport
magnesium transporters
Protein Binding
Signal Transduction
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Volume :
- 13
- Issue :
- 210
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....f54c36daaaf6beaaec239cb1be0c6a12