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SHBG, Sex Hormones, and Inflammatory Markers in Older Women
- Source :
- The Journal of Clinical Endocrinology & Metabolism. 96:1053-1059
- Publication Year :
- 2011
- Publisher :
- The Endocrine Society, 2011.
-
Abstract
- Context: In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation. Objective: The aim of the study was to examine the relationship between SHBG, total testosterone, total E2, and inflammatory markers in older women. Design and Patients: We conducted a retrospective cross-sectional study of 433 women at least 65 yr old from the InCHIANTI Study, Italy, who were not on hormone replacement therapy or recently hospitalized and who had complete data on SHBG, testosterone, E2, C-reactive protein (CRP), IL-6, soluble IL-6 receptor (sIL-6r), and TNF-α. Relationships between sex hormones and inflammatory markers were examined by multivariate linear regression analyses adjusted for age, body mass index, smoking, insulin, physical activity, and chronic disease. Results: In fully adjusted analyses, SHBG was negatively associated with CRP (P = 0.007), IL-6 (P = 0.008), and sIL-6r (P = 0.02). In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-α (P = 0.0002). The negative relationship between testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no longer significant in a fully adjusted model (P = 0.12). E2 was positively associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models. In a final model including E2, testosterone, and SHBG, and all the confounders previously considered, SHBG (0.23 ± 0.08; P = 0.006) and E2 (0.21 ± 0.08; P = 0.007), but not testosterone (P = 0.21), were still significantly associated with CRP. Conclusion: In late postmenopausal women not on hormone replacement therapy, SHBG and E2 are, respectively, negative and positive, independent and significant correlates of a proinflammatory state.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Clinical Biochemistry
Inflammation
Sex Factor
Disease
Gonadal Steroid Hormone
Biochemistry
Sex Factors
Endocrinology
Sex hormone-binding globulin
Retrospective Studie
Sex Hormone-Binding Globulin
Internal medicine
polycyclic compounds
medicine
Endocrine Research
Humans
Age Factor
Gonadal Steroid Hormones
Interleukin 6
Inflammation Mediator
reproductive and urinary physiology
Testosterone
Retrospective Studies
Aged
Aged, 80 and over
Cross-Sectional Studie
biology
Insulin
Biochemistry (medical)
C-reactive protein
Age Factors
Biomarker
Postmenopause
Cross-Sectional Studies
C-Reactive Protein
biology.protein
Female
Inflammation Mediators
medicine.symptom
hormones, hormone substitutes, and hormone antagonists
Biomarkers
Human
Hormone
Subjects
Details
- ISSN :
- 19457197 and 0021972X
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Endocrinology & Metabolism
- Accession number :
- edsair.doi.dedup.....f54d3568cc27de20c46963b8c99ce468