Rh(III)-Catalyzed C–C/C–N Coupling of Imidates with α-Diazo Imidamide: Synthesis of Isoquinoline-Fused Indoles

Imidate esters and diazo compounds have been established as bifunctional substrates for the construction of biologically active fused heterocycles via rhodium-catalyzed C-H activation and C-C/C-N coupling. This reaction occurs under mild conditions with high efficiency, step economy, and low catalyst loading.