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Up-regulated BCAR4 contributes to proliferation and migration of cervical cancer cells
- Source :
- Surgical oncology. 27(2)
- Publication Year :
- 2018
-
Abstract
- OBJECTIVES Recently, thousands of long non-coding RNAs (lncRNAs) involved in development and metastasis of malignant tumors have been identified. Long non-coding RNA (lncRNA) breast cancer anti-estrogen resistance 4 (BCAR4) has been proved to promote proliferation and metastasis in multiple tumors. However, the function and significance of BCAR4 in cervical cancer are still unclear. METHODS In this study, we concentrated on the biological function and clinical significance of BCAR4 in cervical cancer. More specifically, BCAR4 expression was evaluated in cervical cancer tissues and cell lines by qRT-PCR. Moreover, the prognostic factors were assessed by Kaplan-Meier analysis and Cox proportional hazards models. Additionally, functional assays were conducted and the potential mechanism was explored. RESULTS Our study showed that BCAR4 expression was significantly up-regulated in cervical cancer tissue and cell lines. Moreover, patients with high BCAR4 expression showed worse survival outcomes and overexpression of BCAR4 might be an independent prognostic factor in cervical cancer. Furthermore, overexpression of BCAR4 remarkably promoted the proliferation, motility of cervical cancer cells and silencing BCAR4 significantly suppressed the proliferation, migration and invasion of cervical cancer cells. Additionally, overexpression of BCAR4 promoted epithelial-mesenchymal transition (EMT) process and silencing BCAR4 suppressed EMT process in cervical cancer cells. CONCLUSIONS The results indicated that BCAR4 might play a crucial role in cervical cancer progression and act as an underlying biomarker for the diagnosis and prognosis of cervical cancer.
- Subjects :
- 0301 basic medicine
Uterine Cervical Neoplasms
Metastasis
03 medical and health sciences
0302 clinical medicine
Breast cancer
Downregulation and upregulation
Cell Movement
medicine
Biomarkers, Tumor
Tumor Cells, Cultured
Gene silencing
Humans
Clinical significance
Neoplasm Invasiveness
Cell Proliferation
Cervical cancer
business.industry
Middle Aged
medicine.disease
Prognosis
Gene Expression Regulation, Neoplastic
Survival Rate
030104 developmental biology
Oncology
Cell culture
030220 oncology & carcinogenesis
Case-Control Studies
Cancer research
Disease Progression
Biomarker (medicine)
Surgery
Female
RNA, Long Noncoding
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 18793320
- Volume :
- 27
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Surgical oncology
- Accession number :
- edsair.doi.dedup.....f55853577bb1fd1374e8821044fdd54d