Back to Search Start Over

Serum levels of vaspin and visfatin in patients with coronary artery disease—Kozani study

Authors :
Argirios Gkontopoulos
Efstratios K. Theofilogiannakos
Grigorios Fotiadis
Stilianos Lampropoulos
Nikolaos P.E. Kadoglou
George Kottas
Alkistis Kapelouzou
Source :
Clinica Chimica Acta. 412:48-52
Publication Year :
2011
Publisher :
Elsevier BV, 2011.

Abstract

The association of novel adipokines, vaspin and visfatin, with atherosclerosis is still obscure. The present study aimed to investigate the relationship of those adipokines with the existence as well as the extent of coronary artery disease (CAD), suggesting a link between adiposity and atherosclerosis.We enrolled a total of 108 patients with angiographically proven stable, asymptomatic CAD and 65 healthy controls (HC) without cardiovascular diseases. The severity of CAD was assessed using coronary angiography by the Gensini score. Clinical parameters, glycemic and lipid profile, high-sensitivity CRP (hsCRP), vaspin and visfatin levels were assayed.Serum levels of vaspin were significantly lower in subjects with CAD [0.91 (0.44-1.29) ng/ml] than healthy controls [1.42 (0.96-2.42) ng/ml] (p = 0.009). Inversely, visfatin (p = 0.016) and hsCRP (p0.001) levels were considerably up-regulated in CAD vs HC group. Multivariate analysis demonstrated decreased vaspin and increased visfatin levels to correlate with CAD presence, independent of other cardiovascular risk factors (p0.05). Standard multiple regression revealed HDL, LDL-C and vaspin to be independent determinants of Gensini score (R² = 0.189, p = 0.019). Notably, statin-free patients had even lower vaspin levels compared to statin users (p = 0.018).Decreased vaspin and increased visfatin serum levels were observed in asymptomatic patients with CAD. Low vaspin concentrations seemed to correlate with CAD severity.

Details

ISSN :
00098981
Volume :
412
Database :
OpenAIRE
Journal :
Clinica Chimica Acta
Accession number :
edsair.doi.dedup.....f577ff56c02306fec6d375f5f7c18388
Full Text :
https://doi.org/10.1016/j.cca.2010.09.012