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Toward accurate quantitative photoacoustic imaging: learning vascular blood oxygen saturation in three dimensions
- Source :
- Journal of Biomedical Optics
- Publication Year :
- 2020
- Publisher :
- SPIE-Intl Soc Optical Eng, 2020.
-
Abstract
- Significance: Two-dimensional (2-D) fully convolutional neural networks have been shown capable of producing maps of sO2 from 2-D simulated images of simple tissue models. However, their potential to produce accurate estimates in vivo is uncertain as they are limited by the 2-D nature of the training data when the problem is inherently three-dimensional (3-D), and they have not been tested with realistic images. Aim: To demonstrate the capability of deep neural networks to process whole 3-D images and output 3-D maps of vascular sO2 from realistic tissue models/images. Approach: Two separate fully convolutional neural networks were trained to produce 3-D maps of vascular blood oxygen saturation and vessel positions from multiwavelength simulated images of tissue models. Results: The mean of the absolute difference between the true mean vessel sO2 and the network output for 40 examples was 4.4% and the standard deviation was 4.5%. Conclusions: 3-D fully convolutional networks were shown capable of producing accurate sO2 maps using the full extent of spatial information contained within 3-D images generated under conditions mimicking real imaging scenarios. We demonstrate that networks can cope with some of the confounding effects present in real images such as limited-view artifacts and have the potential to produce accurate estimates in vivo.
- Subjects :
- Paper
Computer science
Biomedical Engineering
Absolute difference
01 natural sciences
Convolutional neural network
Standard deviation
Data modeling
010309 optics
Biomaterials
03 medical and health sciences
Imaging, Three-Dimensional
0103 physical sciences
Oximetry
General
quantitative photoacoustics
030304 developmental biology
0303 health sciences
business.industry
Deep learning
deep learning
sO2
Pattern recognition
Image segmentation
Real image
3D modeling
oxygen saturation
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Oxygen
machine learning
Neural Networks, Computer
Artificial intelligence
photoacoustics
Artifacts
business
Subjects
Details
- ISSN :
- 10833668
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Optics
- Accession number :
- edsair.doi.dedup.....f5c66fbf0a34744892422d95fed70ae1