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Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases
- Source :
- Biomedicines, Vol 9, Iss 173, p 173 (2021), Biomedicines
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continuously growing. Curcumin has been proposed for the treatment of several of these pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to the ability of this molecule to reduce inflammation and aggregation of involved proteins. Nevertheless, the poor metabolic stability and bioavailability of curcumin reduce the possibilities of its practical use. For these reasons, many curcumin derivatives were synthetized in order to overcome some limitations. In this review will be highlighted recent results on modification of curcumin scaffold in the search of new effective therapeutic agents against NDs, with particular emphasis on AD.
- Subjects :
- Scaffold
Drug discovery
business.industry
Medicine (miscellaneous)
amyloid
Settore CHIM/06 - Chimica Organica
Review
Disease
Metabolic stability
Bioinformatics
General Biochemistry, Genetics and Molecular Biology
chemistry.chemical_compound
chemistry
lcsh:Biology (General)
Curcumin
Medicine
curcumin
tau
business
Alzheimer’s disease
lcsh:QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 22279059
- Volume :
- 9
- Issue :
- 173
- Database :
- OpenAIRE
- Journal :
- Biomedicines
- Accession number :
- edsair.doi.dedup.....f5ebe6c862e184e4ffbcfef1dcc6d53b