The mechanism and pharmacodynamics of 2-((1H-indol-3-yl)thio/sulfinyl)-N-pheny acetamide derivative as a novel inhibitor against human respiratory syncytial virus

Authors :: Ningning, Cheng
Nan, Jiang
Yuanhui, Fu
Zhuxin, Xu
Xianglei, Peng
Jiemei, Yu
Shan, Cen
Yucheng, Wang
Guoning, Zhang
Yanpeng, Zheng
Jinsheng, He
Source :: Journal of Enzyme Inhibition and Medicinal Chemistry. 37:2598-2604
Publication Year :: 2022
Publisher :: Informa UK Limited, 2022.
Abstract: Human respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infection worldwide. Until now, there are no licenced vaccines or effective antiviral drugs against RSV infections. In our previous work, we found 2-((1H-indol-3-yl)thio/sulfinyl)-N-pheny acetamide derivatives (4-49 C and 1-HB-63) being a novel inhibitor against RSV

Subjects :: Pharmacology
Mice
Mice, Inbred BALB C
Respiratory Syncytial Virus, Human
Acetamides
Drug Discovery
Animals
Humans
Respiratory Syncytial Virus Infections
General Medicine
Virus Replication
Amides
Antiviral Agents

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