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The Role of the Casein Kinase 1 (CK1) Family in Different Signaling Pathways Linked to Cancer Development
- Source :
- Oncology Research and Treatment. 28:508-514
- Publication Year :
- 2005
- Publisher :
- S. Karger AG, 2005.
-
Abstract
- The members of the casein kinase 1 (CK1) family are highly conserved and are expressed in many eukaryotes ranging from yeast to humans. Mammalian CK1 isoforms (alpha, beta, gamma, delta, epsilon) and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Mutations and deregulation of CK1 expression and activity has been linked to various diseases including neurodegenerative disorders such as Alzheimer's and Parkinson's disease, sleeping disorders and proliferative diseases such as cancer. In this review, we summarize the functions of CK1 and outline the participation of CK1 in signal transduction pathways linked to cancer development.
- Subjects :
- Cancer Research
Cellular differentiation
Apoptosis
Biology
Neoplasms
Casein kinase 2, alpha 1
medicine
Animals
Humans
Protein Isoforms
Cell Proliferation
Regulation of gene expression
Genetics
Casein Kinase I
Cell growth
Cancer
Hematology
medicine.disease
Neoplasm Proteins
Cell biology
Gene Expression Regulation, Neoplastic
Isoenzymes
Oncology
Casein kinase 1
Casein kinase 2
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 22965262 and 22965270
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Oncology Research and Treatment
- Accession number :
- edsair.doi.dedup.....f5f67bf38ae56b387e3d644ac624de3e
- Full Text :
- https://doi.org/10.1159/000087137