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Stress, Glucocorticoids and Bone: A Review From Mammals and Fish
- Source :
- Frontiers in Endocrinology, Vol 9 (2018), Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2018
-
Abstract
- 8 pages, 1 table, 1 figure<br />Glucocorticoids (GCs) are the final effector products of a neuroendocrine HPA/HPI axis governing energy balance and stress response in vertebrates. From a physiological point of view, basal GC levels are essential for intermediary metabolism and participate in the development and homeostasis of a wide range of body tissues, including the skeleton. Numerous mammalian studies have demonstrated that GC hormones exert a positive role during bone modeling and remodeling as they promote osteoblastogenesis to maintain the bone architecture. Although the pharmacological effect of the so-called stress hormones has been widely reported, the role of endogenous GCs on bone mineral metabolism as result of the endocrine stress response has been largely overlooked across vertebrates. In addition, stress responses are variable depending on the stressor (e.g., starvation, predation, and environmental change), life cycle events (e.g., migration and aging), and differ among vertebrate lineages, which react differently according to their biological, social and cognitive complexity (e.g., mineral demands, physical, and psychological stress). This review intends to summarize the endogenous GCs action on bone metabolism of mammals and fish under a variety of challenging circumstances. Particular emphasis will be given to the regulatory loop between GCs and the parathyroid hormone (PTH) family peptides, and other key regulators of mineral homeostasis and bone remodeling in vertebrates.<br />This work was funded by the Spanish Economy and Competitiveness Ministry projects AGL2014-52473R and AGL2017-89648P to JR. PS-B was supported by AGL2014-52473R and AGL2017-89648P project contracts. PG acknowledges the Portuguese Foundation for Science and Technology (project grant PTDC/BIA-ANM/4225/2012).
- Subjects :
- 0301 basic medicine
Endocrinology, Diabetes and Metabolism
Parathyroid hormone
030209 endocrinology & metabolism
Endogeny
bone
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Bone remodeling
PTH3
Bream Sparus-Aurata
03 medical and health sciences
stress
Plasma-cortisol
0302 clinical medicine
Endogenous glucocorticoids
biology.animal
Healthy elderly-men
Endocrine system
2. Zero hunger
lcsh:RC648-665
Osteoblast differentiation
biology
glucocorticoids
Water rainbow-trout
Calcium-transport
Stressor
Vertebrate
PTHLH
Mineral density
Cell biology
Hormone-related protein
030104 developmental biology
vertebrates
Spawning migration
Homeostasis
Hormone
Subjects
Details
- ISSN :
- 16642392
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in endocrinology
- Accession number :
- edsair.doi.dedup.....f60958be92705935ea3e91a6847e0ef7